Xenleta vs. Cipro

Xenleta(lefamulin) andCipro(ciprofloxacin) are antibiotics used to treat different types of细菌infections.

Xenleta is used to treat adults with community-acquired细菌pneumonia(CABP) caused by susceptible microorganisms.

Cipro is used to treat infections of theskin,lungs, airways, bones, joints, and尿路infections caused by susceptiblebacteria.

Xenleta and Cipro are different types of antibiotics. Xenleta is a pleuromutilinantibacterialand Cipro is a fluoroquinoloneantibiotic.

Side effectsof Xenleta and Cipro that are similar includesleepproblems (insomniaor nightmares),headache,diarrhea,nausea, and vomiting.

Side effects of Xenleta that are different from Cipro include injection site reactions, elevatedliverenzymes, and lowbloodpotassium.

Side effects of Cipro that are different from Xenleta includedizziness, drowsiness,stomachupset,abdominal pain,blurred vision, nervousness,anxiety, agitation,rash, andconnective tissueproblems (tendonruptureandjointproblems).

Both Xenleta and Cipro may interact withantidepressantsandheartrhythm medications.

Xenleta may also interact with strong CYP3A4 inducers or P-gp inducers, strong CYP3A inhibitors or P-gp inhibitors,阿普唑仑, diltiazem,verapamil,simvastatin,vardenafil, antipsychotics,erythromycin, and moxifloxacin.

Cipro may also interact with咖啡因,sucralfate;antacidsthat containcalcium,magnesium, oraluminum; didanosine, lanthanum carbonate or sevelamer; vitamin or mineral supplements that contain calcium,iron, magnesium, orzinc;cyclosporine,methotrexate,metoclopramide,phenytoin, probenecid, ropinirole,sildenafil,theophylline, blood thinners,diuretics(waterpills),insulinororaldiabetesmedicines, medicines to treat mental illness, steroids, and nonsteroidalanti-inflammatory drugs (NSAIDs).

Common side effects of Xenleta include:

• 注射部位反应,
• elevated liver enzymes,
• nausea,
• low blood potassium,
• insomnia,
• headache,
• diarrhea,
• nausea, and
• vomiting

Common side effects of Cipro include:

• diarrhea
• dizziness
• drowsiness
• headache
• stomach upset
• abdominalpain
• nausea/vomiting
• blurred vision
• nervousness
• anxiety
• agitation
• sleep problems (insomnia or nightmares), and
• rash

Tell yourdoctorif you experience serious side effects of Cipro including severe dizziness,fainting, fast or pounding heartbeats; sudden pain, snapping or popping sound, bruising, swelling, tenderness, stiffness, or loss of movementinany of your joints; watery or bloody diarrhea; confusion, hallucinations,depression, unusual thoughts or behavior;seizure(convulsions); severe headache, ringing in your ears, pain behind your eyes; pale or yellow skin, dark coloredurine,fever, weakness; urinating less than usual or not at all; easy bruising or bleeding; numbness, tingling, or unusual pain anywhere in your body; the firstsignof any skin rash, no matter how mild; or severe skin reaction -- fever,sore throat, swelling in your face ortongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Xenleta (lefamulin) is a pleuromutilin antibacterial indicated for the treatment of adults with community-acquired bacterial pneumonia (CABP) caused by susceptible microorganisms.

Cipro (ciprofloxacin) is a quinolone antibiotic. Cipro is available as ageneric drugand is prescribed to treat infections of the skin, lungs, airways, bones, joints, andurinarytract infections caused by susceptible bacteria.

Xenleta may interact with strong CYP3A4 inducers or P-gp inducers, strong CYP3A inhibitors or P-gp inhibitors, alprazolam, diltiazem, verapamil, simvastatin, vardenafil, antiarrhythmics, antipsychotics, erythromycin, moxifloxacin, andtricyclic antidepressants. Tell your doctor all medications and supplements you use. Xenleta is not recommended for use duringpregnancy; it may harm afetus. Females of reproductive potential are advised to use effective contraception during treatment with Xenleta and for 2 days after the final dose. It is unknown if Xenleta passes intobreast milk. Because of the potential for adverse reactions innursinginfants,breastfeedingis not recommended while using Xenleta. Women should pump and discardbreastmilk for the duration of treatment with Xenleta and for 2 days after the final dose.

Cipro may also interact withtizanidine,clozapine, cyclosporine,glyburide, methotrexate, metoclopramide, phenytoin, probenecid, ropinirole, theophylline, nonsteroidal anti-inflammatory drugs (NSAIDs) or steroids.

环丙沙星也可能与不互动her medicines that make you sleepy (such as cold orallergymedicine, sedatives,narcoticpain medicine, sleeping pills,musclerelaxers, and medicine for seizures, or anxiety),digoxin, metoclopramide,atropine,belladonna,benztropine, dimenhydrinate, methscopolamine,scopolamine, bronchodilators,bladderor urinary medications, heart rhythm medications, irritablebowelmedications, nitrates, steroids, orulcermedications.

The recommended dosage of Xenleta is 150mgevery 12 hours byintravenousinfusion over 60 minutes for 5 to 7 days or 600 mg orally every 12 hours for 5 days.

• Take Cipro exactly as your healthcare provider tells you to take it.
• Your healthcare provider will tell you how much Cipro to take and when to take it.
• Take Cipro Tablets in the morning and evening at about the same time each day. Swallow thetabletwhole. Do not split, crush or chew the tablet. Tell your healthcare provider if you cannot swallow the tablet whole.
• Take Cipro Oral Suspension in the morning and evening at about the same time each day. Shake the Cipro Oral Suspension bottle well each time before use for about 15 seconds to make sure the suspension is mixed well. Close the bottle completely after use.
• TakeCipro XRone time each day at about the same time each day. Swallow the tablet whole. Do not split, crush or chew the tablet. Tell your healthcare provider if you cannot swallow the tablet whole.
• Cipro IVis given to you by intravenous (IV) infusion into yourvein, slowly, over 60 minutes, as prescribed by your healthcare provider.
• Cipro can be taken with or withoutfood.
• Cipro should not be taken with dairy products (like milk oryogurt) or calcium-fortified juices alone, but may be taken with a meal that contains these products.
• Drink plenty of fluids while taking Cipro.
• Do not skip any doses of Cipro, or stop taking it, even if you begin to feel better, until you finish your prescribed treatment unless:
  • you have tendon problems. See“What is the most important information I should know about Cipro?”
  • you havenerveproblems. See“What is the most important information I should know about Cipro?”
  • you havecentral nervous systemproblems. See“What is the most important information I should know about Cipro?”
  • you have a seriousallergic reaction. See“What are the possible side effects of Cipro?”
  • your healthcare provider tells you to stop taking Cipro

把所有的your Cipro doses will help make sure that all of the bacteria are killed. Taking all of your Cipro doses will help lower the chance that the bacteria will become resistant to Cipro. If you become resistant to Cipro, Cipro and other antibacterial medicines may not work for you in the future.

• If you take too much Cipro, call your healthcare provider or get medical help right away.