![kesimpta](https://images.medicinenet.com/images/article/main_image/what-is-kesimpta.jpg?output-quality=75)
Kesimpta is a brand name for ofatumumab (formerly OMB157), a targeted B-cell medication to treat the relapsing forms ofmultiple sclerosis(RMS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. It is licensed and distributed by Novartis.
Multiple sclerosis(MS) is a debilitating disorder of the brain and spinal cord, which has an autoimmune etiology. It is characterized by muscleweakness, balance problems, visual disturbances, painful sensations in the limbs, and neck and memory problems.
The CD-20 protein present on B type of lymphocytes (white blood cells) plays a role in the development ofMS. Suppressing this protein may help reduce the neuronal inflammation seen in RMS, which lowers the severity and duration of the relapse.
Kesimpta is an anti-CD20 monoclonal antibody that suppresses the CD20 protein on lymphocytes by binding to a distinct fragment on the molecule of CD20. This causes B-cell destruction. It comes in a targeted and specific selective delivery system that allows precise delivery to thelymph nodes, where B-cell depletion inMSis needed.
- Kesimpta can be self-administered at designated subcutaneous injections sites one time a month.
- Kesimpta may soon become the first-line therapy for the management ofmultiple sclerosis.
How is Kesimpta administered?
The first dose of Kesimpta is always administered under a doctor’s supervision. The subsequent doses can be administered at home.
The recommended dosage schedule is:
- First dose:与20毫克剂量的Kesimp皮下注射ta at weeks zero, one, and two.
- Subsequent doses:Also of 20 mg via subcutaneous injection one time a month, beginning at week four.
Kesimpta self-administration tips
- You should clean the area with analcoholswab and let it dry.
- Pinch the area between your index finger and thumb and gently inject the required dose.
- The recommended site for Kesimpta is in the abdomen, thigh, or outer upper arm.
- Do not inject intomoles,scars,stretch marks, or areas where the skin is wounded, infected, tender, bruised, red, or scaly.
If you miss a dose of Kesimpta, administer it as soon as possible without waiting until the next scheduled dose. You may then take the next doses at the recommended intervals without changing the previous schedule.
Kesimpta sensoready pens and syringes are for single use only. Make sure you discard them as recommended on the inserts.
他不应该德e Kesimpta?
Research is underway to understand the side effects and safety levels of ofatumumab containing Kesimpta. However, certain individuals should not take these injections.
Those withHepatitis B(HVB) infection should never take Kesimpta. Your healthcare provider will check your blood forHepatitis Binfection before initiating the therapy.
- If you have a history ofHBVinfection, the virus could reactivate during or after the treatment with Kesimpta.
- If you have an activehepatitis Bliver disease, your healthcare provider will not initiate the treatment until the virus is completely out of your system.
- Your healthcare provider will monitor you for HBV infection during and after you stop using Kesimpta.
Kesimpta can causeliverfailure and death in those with HBV infection.
- Kesimpta weakens your immune system and may increase your risk of getting serioussepsis.
- Progressive multifocal leukoencephalopathyis a rare, serious brain infection caused by a virus and can result in death or severe disability. Kesimpta can trigger disease progression by weakening your immunity. Contact your doctor if you experience any new or worsening neurologic symptoms, such as unilateral body weakness,vision loss, loss of coordination in the limbs,mood changes, or personality changes.
Injection-related reactions of Kesimpta include side effects such as:
![](https://images.medicinenet.com//images/slideshow/multiple-sclerosis-s1-brain-spinal-cord-nerves.jpg)
SLIDESHOW
What Is Multiple Sclerosis? MS Symptoms, Causes, DiagnosisSee SlideshowNovartis Pharmaceuticals Corporation. Highlights of prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/125326s070lbl.pdf
Novartis Pharmaceuticals Corporation. Medication guide. https://www.novartis.us/sites/www.novartis.us/files/kesimpta_pmg.pdf
Top What Is Kesimpta Related Articles
MS (Multiple Sclerosis) vs. ALS (Amyotrophic Lateral Sclerosis)
ALS (amyotrophic lateral sclerosis, Lou Gehrig's disease) and MS (multiple sclerosis) are both diseases of the nervous system (neurodegenerative). ALS is a disease in which the nerve cells in the body are attacked by the immune system, although it's not considered an autoimmune disease by some scientists. MS is an autoimmune disease in which the insulated covering of the nerves (myelin sheath) in the CNS (central nervous system) degenerate, or deteriorate.
Scientists don't know the exact cause of either problem. However, they have discovered that mutations in the gene that produces the SOD1 enzyme were associated with some cases of familial ALS. Scientists also theorize that multiple sclerosis may be caused by infection or vitamin D deficiency. ALS occurs between 50-70 years of age (the average age of occurrence ALS is 55), and mostly affects men. While MS occurs between 20-60 years of age, and mostly affects women. About 30,000 people in the US have ALS, and an average of 5,000 new diagnoses per year (that's about 15 new cases per week). Worldwide, MS affects more than 2.3 million people, with about 10,000 new cases diagnosed each year (that's about 200 new diagnoses per week).
Some of the signs and symptoms of both diseases include muscle weakness, muscle spasms, problems walking, fatigue, slurred speech, and problems swallowing. ALS signs and symptoms that are different from MS include problems holding the head upright, clumsiness, muscle cramps and twitches, problems holding objects, and uncontrollable periods of laughing or crying. MS signs and symptoms that are different from ALS include vision problems, vertigo and balance problems, sexual problems, memory problems, depression, mood swings, and digestive problems.There is no cure for either disease, however the prognosis and life expectancy are different. Multiple sclerosis is not a fatal condition, while ALS progresses rapidly and leads to death.
Alternative Treatment (CAM) for MS
The term alternative therapy, in general, is used to describe any medical treatment or intervention that has not been scientifically documented or identified as safe or effective for a specific condition. Alternative therapy encompasses a variety of disciplines that range from diet and exercise to mental conditioning to lifestyle changes.Botox to Treat Multiple Sclerosis (MS)
Botulinum toxin is a muscle-relaxing medication used to decrease spasticity related to multiple sclerosis and other neurological conditions. Botulinum toxin is derived from the bacterium梭状芽胞杆菌botulinum. There are three types of botulinum toxin available for therapeutic use.Can Stress Cause Multiple Sclerosis (MS)?
Multiple sclerosis (MS) results when your immune system attacks the cells of the brain and spinal cord. It is an autoimmune disease, a condition in which the body's immune system is misdirected and attacks its own cells. Stress can make it difficult for a person to manage MS symptoms. Regular exercise and mindful eating have been found to control the stress levels and overall health of people with MS.多发性硬化(MS)会传染吗?
Multiple sclerosis, or MS, is a degenerative disease of the covering around the nerves in the central nervous system (CNS). Researchers and doctors don't know the exact cause, but many theorize that it may be due to environmental triggers, an autoimmune disease, and viruses (infections). Symptoms and signs of MS include vision changes, paralysis, vertigo, heat intolerance, slurred speech, sexual dysfunction, and urinary incontinence (the inability to urinate). There's no vaccine or cure for MS, but the progression and symptoms of the disease can be treated.Multiple Sclerosis (MS) Symptoms and Treatments
Multiple sclerosis (MS) symptoms vary from person to person and can last for days to months without periods of remission. Symptoms of MS include sexual problems and problems with the bowel, bladder, eyes, muscles, speech, swallowing, brain, and nervous system. The early symptoms and signs of multiple sclerosis usually start between ages 20-40. MS in children, teens, and those over age 40 is rare. Treatment options for multiple sclerosis vary depending on the type and severity of symptoms. Medications may be prescribed to manage MS symptoms.Multiple Sclerosis (MS)
多发性硬化症或女士是一种自身免疫性疾病in which brain and spinal cord nerve cells become demyelinated. This damage results in symptoms that may include numbness, weakness, vertigo, paralysis, and involuntary muscle contractions. Different forms of MS can follow variable courses from relatively benign to life-threatening. MS is treated with disease-modifying therapies. Some MS symptoms can be treated with medications.Making an MS Friendly Home
Adults with multiple sclerosis may be at risk for injuries, hazards, and falling at home. Some simple home modifications can protect your health and safety and facilitate fall prevention. Reduce your risk of accidents and prevent hazards with these tips.Multiple Sclerosis (MS) and Pregnancy
Multiple sclerosis or MS is a central nervous system disease in which the immune system attacks the myelin sheath (the protective coating around nerves). Symptoms of MS include pain, sexual problems, fatigue, numbness and tingling, emotional changes, and depression.Women who are pregnant and have multiple sclerosis may have more difficulty carrying a pregnancy. Multiple sclerosis does not affect ability to conceive, and does not seem to affect fertility. MS symptoms during pregnancy may stay the same or get better; however, they may worsen after giving birth. Pregnancy decreases the number of relapses, but flares increase in the first 3-6 months after delivery. Pregnant women with MS may carrying a pregnancy more difficult to tell when labor starts, and there is an increased need to use forceps or vacuum to assist with delivery or b7 C-section (Cesarean birth) increases.
Some treatment MS drugs may be safe to use during pregnancy; however, some drugs should not be taken, for example, baclofen (Gablofen, Lioresal), fluoxetine (Prozac, Sarafem), or solifenacin succinate (VESIcare), and most disease-modifying therapies (DMTs).
Talk with your healthcare team about vitamins, supplements, and medications that you are taking if you are pregnant and have MS.
Multiple Sclerosis (MS) Early Warning Signs and Types
Multiple sclerosis (MS) can be thought of as an immune-mediated inflammatory process involving different areas of the central nervous system (CNS) at various points in time. Early warning signs and symptoms of MS in children, teens, and adults are similar; however, children and teens with pediatric also may have seizures and a complete lack of energy. Adults with MS do not have these signs and symptoms. Other signs and symptoms of MS include inflammation of the optic nerve (optic neuritis), changes in vision, Wiping or having tissues around the eye and moving the eye may be painful, and double vision. There are four types of MS, relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), primary progressive MS (PPMS), and progressive relapsing MD (PRMS).MS Quiz
Multiple Sclerosis is a debilitating neurological condition. Take the MS Quiz to test your knowledge of the causes, symptoms, risks and treatments.MS Slideshow
MS is an autoimmune disease that attacks the nerves of the central nervous system. Learn about multiple sclerosis (MS) causes, symptoms, and treatment, along with diagnosis and life expectancy.Famous Faces of MS
Learn about celebrities, such as Montel Williams and Jack Osbourne, who are living with multiple sclerosis.Multiple Sclerosis Symptoms Picture
Symptoms of multiple sclerosis may be single or multiple and may range from mild to severe in intensity and short to long in duration. See a picture of Multiple Sclerosis Symptoms and learn more about the health topic.Who Is at High Risk for Multiple Sclerosis?
The cause of multiple sclerosis (MS) is not known. But scientists believe that a combination of various factors may put an individual at a higher risk for MS. These factors include immunologic factors, environmental factors, low vitamin D levels, smoking, obesity, Epstein-Barr virus, genetics, and the female gender.