Tradjenta vs. Glucotrol

Tradjenta(linagliptin) andGlucotrol(glipizide) areoraldiabetesmedicines used as adjuncts to diet and exercise to improve glycemiccontrolinadults withtype 2 diabetesmellitus.

Side effectsof Tradjenta and Glucotrol that are similar include weight gain andheadache.

Side effects of Tradjenta that are different from Glucotrol includestuffy nose,流鼻涕,sore throat,cough,muscleorjointpain,back pain, or低血糖.

Side effects of Glucotrol that are different from Tradjenta includediarrhea,constipation,nausea, vomiting, upsetstomach, loss of appetite,skinchanges (skinrash,hives, redness,itching, and blisters), gas, drowsiness, anddizziness.

Both Tradjenta and Glucotrol may interact with nonsteroidalanti-inflammatory drugs (NSAIDs), some azole antifungals, sulfa drugs, probenecid, monoamine oxidase inhibitors (MAOIs), beta-blockers, andseizuremedications.

Tradjenta may also interact with bosentan,dexamethasone, quinidine,verapamil, rifabutin,rifampin, rifapentine, St. John's wort,barbiturates,medicationto treatHIV/AIDS, medicines to treatnarcolepsy, medicines used to preventorgantransplantrejection,aspirinor other salicylates (including Pepto-Bismol), or other oral diabetes medications.

Glucotrol may also interact withalcohol, and other drugs that are highlyproteinbound, salicylates,chloramphenicol, coumarins, quinolones,diuretics, corticosteroids, phenothiazines,thyroid产品,estrogens, oral contraceptives,nicotinic acid, sympathomimetics,calciumchannel blockers, colesevelam, andisoniazid.

Common side effects of Tradjenta include:

• stuffynose,
• 流鼻涕,
• sorethroat,
• 咳嗽,
• weight gain,
• muscle or joint pain,
• headache,
• back pain, or
• lowblood sugar.

Tradjenta may cause serious side effects, including:

• inflammationof thepancreas(pancreatitis, symptoms include severe pain in your upper stomach spreading to your back, nausea and vomiting,
• loss of appetite,
• fastheart rate),
• fever, and headache with a severe blistering, peeling, and red skin rash.

Common side effects of Glucotrol include:

• diarrhea
• constipation
• nausea
• vomiting
• upset stomach
• loss of appetite
• headache
• weight gain,
• skin changes (skin rash, hives, redness, itching, and blisters)
• gas
• drowsiness, and
• dizziness

Tell yourdoctorif you experience serious side effects of Glucotrol including easy bruising or bleeding (nosebleeds, bleeding gums),tiredness,shortness of breath, upper stomach pain, itching, darkurine, clay-colored stools,jaundice(yellowing of the skin or eyes); pale skin, fever, confusion; or throbbing headache, severe nausea and vomiting, fast or pounding heartbeats,sweatingor thirst, or feeling like you might pass out.

Tradjenta (linagliptin) tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2diabetes mellitus.

Glucotrol (glipizide) isblood glucoselowering drug of thesulfonylureaclass used to help maintainglucosecontrol in type 2 diabetics, in conjunction with an appropriate diet and exercise program. Glucotrol is available as ageneric命名glipizide.

Tradjenta may interact with bosentan, dexamethasone,ketoconazole, quinidine, verapamil, rifabutin, rifampin, rifapentine, St. John's wort,phenobarbitaland other barbiturates, medication to treat HIV or AIDS, medicines to treat narcolepsy, medicines used to prevent organ transplant rejection,seizure medications, probenecid, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates (including Pepto-Bismol), sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, or other oral diabetes medications. Tell your doctor all medications and supplements you use. Tell your doctor if you arepregnantor plan to become pregnant before using Tradjenta; it is not expected to harm an unborn baby. It is unknown if Tradjenta passes intobreast milkor if it could harm anursingbaby. Consult your doctor beforebreastfeeding.

Many drugs may interact with Glucotrol; patients should carefully check glucose levels and inform their doctors about what medications they are taking. There are no adequate and well controlled studies of Glucotrol in pregnant women. Glucotrol (glipizide) should be used duringpregnancyor breastfeeding women only if the potential benefit justifies the potential risk to thefetusandinfant.

The recommended dose of Tradjenta is 5mgonce daily.

Glucotrol is available in 5 and 10 mg strength tablets. The usual starting dose is 5 mg about 30 min before breakfast.