Toxicepidermalnecrolysis(TEN) is a potentially life-threatening disorder that produces widespread blistering and peeling of the skin. TEN is most commonly induced by a drug (for example, an抗生素or other medication), but other triggers occasionally cause TEN (triggers like an infection or a malignancy). With severe TEN, occasionally the barrier and containment properties of the skin are dangerously compromised and the patient's condition resembles that of a burn patient.
Early treatment involves identifying thetriggeror causative drug or agent and removing or keeping the compound away from the patient. Hospitalization is recommended; for severe TEN, a burn unit is suggested. Other treatments may include the following:
- IV fluids, carefully monitor
- Protective bandages especially where the skin has peeled off
- Ointments
- Pain control
- Antibiotics or antivirals
- IVimmunoglobulin G
- Anticonvulsants
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References
Jameson, J. Larry, et al.Harrison's Principles of Internal Medicine, 20th Ed.New York: McGraw-Hill Education, 2018.