Thymus Extract

Other Name(s):

Complexe de Peptides Thymiques, Extracto de Timo, Extrait de Thymus, Extrait Thymique, Polypeptides Dérivés de Thymus, Predigested Thymus Extract, Protéine Thymique, Pure Thymic Extract, Thymic Extract, Thymic Peptide, Thymic Protein, Thymic Protein A, Thymomodulin, Thymosin, Thymosine, Thymostimulin, Thymostimuline, Thymus, Thymus Acid Lysate Derivative, Thymus Complex, Thymus Concentrate, Thymus-Derived Polypeptides, Thymus Factors, Thymus Polypeptides, Thymus Substance.

Overview

Thymus extract is a chemical that can be man-made or produced from the glands of cows.

Thymus extract is used for infectious diseases including recurrent respiratory infections, colds, flu, H1N1 “swine” flu, hepatitis B, hepatitis C, Epstein-Barr virus (EBV), mononucleosis, herpes and shingles, sinusitis, and AIDS/HIV. It is also used for asthma, hay fever, food allergies, cancer, rheumatoid arthritis (RA), chronic fatigue syndrome (CFS), and systemic lupus erythematosus (SLE). Other uses include maintaining white cell production in cancer patients treated with radiation or chemotherapy, and preventing the effects of aging.

The quality and potency of thymus extract products can vary greatly.

How does it work?

Thymus extract works by improving or boosting the immune system.

SLIDESHOW

What Is Asthma? Symptoms, Causes, and TreatmentsSee Slideshow

Uses & Effectiveness

Possibly Effective for...

  • Hay fever. There is some evidence that treatment for 4 months with calf thymus extract might reduce the number of allergic episodes in people with hay fever.
  • Asthma. Taking calf thymus extract may reduce acute asthma attacks in children with asthma for up to one year.
  • Heart muscle disease (cardiomyopathy). Early research suggests that taking calf thymus extract along with usual therapy improves the ability to exercise, heart function, symptoms, and survival in people with a specific heart disease called cardiomyopathy.
  • Food allergies. Taking calf thymus extract while following an elimination diet might prevent allergic reactions to food.
  • Lung infections. Taking calf thymus extract by mouth seems to reduce the number of infections or coughing attacks in patients who get repeat respiratory infections. Calf thymus extract alone, or in combination with vaccine, seems to be more effective than vaccine alone or antibiotics in reducing the number and duration of infections in adults with recurrent respiratory infections.

Insufficient Evidence to Rate Effectiveness for...

  • AIDS/HIV.
  • Arthritis.
  • Cancer.
  • Herpes.
  • Shingles.
  • Other conditions.
More evidence is needed to rate the effectiveness of thymus extract for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate(detailed description of each of the ratings).

Side Effects

Thymus extract isPOSSIBLY SAFEfor most people when taken by mouth appropriately.

Because thymus can come from animals, there is concern about possible contamination with diseased animal parts. Any products made from contaminated or diseased organs might present a human health hazard. However, so far, there are no reports of disease transmission to humans due to use of contaminated thymus extract.

QUESTION

Asthma is a chronic respiratory disease.See Answer

Special Precautions & Warnings

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking thymus extract if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Weakened immune system: People who have a weakened immune system (HIV/AIDS patients, for example) or people who are taking drugs to weaken their immune system (organ transplant recipients, for example) have a higher risk of infection. These people should avoid thymus extract products unless these products are certified germ-free.

Interactions


Medications that decrease the immune system (Immunosuppressants)Interaction Rating:ModerateBe cautious with this combination.Talk with your health provider.

药物的免疫系统可以降低crease your chances of getting sick. Thymus extract is made from animals. There is some concern that products made from animals might contain harmful diseases and cause infections. Taking medications that decrease the immune system along with thymus extract might increase your chances of getting sick. Do not take thymus extract if you are taking medications that decrease the immune system.

Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral,Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506,Prograf), sirolimus (Rapamune),prednisone(Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • 一个典型的日剂量为750毫克的原油胸腺波尔ypeptide fraction or 120 mg of pure thymus polypetides (thymomodulin).

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References

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Cianciara, J., Babiuch, L., Gorska, E., and Kassur, B. [Immunotherapy of chronic active hepatitis (HBsAg+) with calf thymus extract (TFX-Polfa). Clinical evaluation]. Pol.Tyg.Lek. 8-13-1984;39(33):1097-1101. View abstract.

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Cunningham-Rundles, S., Harbison, M., Guirguis, S., Valacer, D., and Chretien, P. B. New perspectives on use of thymic factors in immune deficiency. Ann N.Y.Acad.Sci 8-15-1994;730:71-83. View abstract.

Cybulski, L., Turowski, G., Politowski, M., Urban, A., Turaszwili, T., and Zubel, M. Initial observations on the administration of thymus extract (TFX) in patients with alimentary tract neoplasms. Pol.Med Sci Hist Bull. 1976;15(1):47-49. View abstract.

Falchi De Maria, D, a . M。Armaroli, L, Balli,M., Bortolus, R., Busutti, L., Busetto, M., Polico, R., Emiliani, E., and Maranzato, G. T-lymphocyte subsets in cancer patients undergoing radiotherapy and their recovery after thymostimulin treatment. A cooperative study. Rays 1993;18(3):438-453. View abstract.

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Hamprecht, K., Votsch, W., and Anderer, F. A. Activation of human monocyte and natural killer cell-mediated tumour cell killing by two dialysable thymic factors. Scand J Immunol 1986;24(1):59-71. View abstract.

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J。,Holowiecki Duraj, M, Rudzka, E, Jarczok K。, Krawczyk, M., Holowiecka, B., Kniewska, I., Kusnierczyk, J., Opala, G., Stanczuk, M., and . Cooperative randomized studies on the treatment of adult acute leukemia in Poland. A comparison of two remission induction regimes and two maintenance regimes for AML. Folia Haematol.Int Mag.Klin.Morphol.Blutforsch. 1984;111(2):201-207. View abstract.

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Jablonowska, E., Tchorzewski, H., Lewkowicz, P., and Kuydowicz, J. Reactive oxygen intermediates and serum antioxidative system in patients with chronic C hepatitis treated with IFN-alpha and thymus factor X. Arch Immunol.Ther Exp (Warsz.) 2005;53(6):529-533. View abstract.

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Lau, B. H., Li, L., and Yoon, P. Thymic peptide protects vascular endothelial cells from hydrogen peroxide-induced oxidant injury. Life Sci. 1993;52(22):1787-1796. View abstract.

Lazzarin, A., Galli, M., Moriondo, P., Parravicini, C., Poli, G., and Moroni, M. Increase of OKT4+ cells during treatment with thymostimulin in parenteral drug addicts with persistent generalized lymphadenopathy. J Clin Lab Immunol 1986;20(2):57-61. View abstract.

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Lersch, C., Zeuner, M., Bauer, A., Siemens, M., Hart, R., Drescher, M., Fink, U., Dancygier, H., and Classen, M. Nonspecific immunostimulation with low doses of cyclophosphamide (LDCY), thymostimulin, and Echinacea purpurea extracts (echinacin) in patients with far advanced colorectal cancers: preliminary results. Cancer Invest 1992;10(5):343-348. View abstract.

Lewandowicz, J. [Effect of thymus extract TFX (Polfa) on hemoglobin level and peripheral blood erythrocyte count]. Pol.Tyg.Lek. 6-4-1990;45(23-24):471-472. View abstract.

Lewandowicz, J. [Immediate results of the treatment of patients with rheumatoid arthritis with a thymus preparation]. Pol.Tyg.Lek. 6-15-1987;42(24):743-744. View abstract.

Li, L., Clark, K., and Lau, B. H. Thymic peptides increase glutathione level and glutathione disulfide reductase activity in vascular endothelial cells. Biotechnol.Ther 1994;5(1-2):87-97. View abstract.

Liberati, A. M., Ballatori, E., Fizzotti, M., Schippa, M., Cini, L., Cinieri, S., Proietti, M. G., Di Marzio, R., Senatore, M., and Grignani, F. A randomized trial to evaluate the immunorestorative properties of thymostimulin in patients with Hodgkin's disease in complete remission. Cancer Immunol.Immunother. 1988;26(1):87-93. View abstract.

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Mondola, P., Santillo, M., Santangelo, F., Belfiore, A., Gambardella, P., and Bifulco, M. Effects of a new calf thymus protein on 3-hydroxy-3-methylglutaryl-CoA reductase activity in rat (Rattus bubalus) hepatocyte cells (BRL-3A). Comp Biochem.Physiol B 1992;103(2):431-434. View abstract.

Muller, H., Mayer, G., Behnke, B., Heimuller, E., Hamscher, G., Immler, D., Siethoff, C., Meyer, H. E., and Schreiber, M. Enhancing of anti-viral activity against HIV-1 by stimulation of CD8+ T cells with thymic peptides. Clin Exp Immunol. 1999;117(1):76-83. View abstract.

Mustacchi, G., Pavesi, L., Milani, S., Iaffaioli, V., Caraco, A., Comella, G., Contu, A., Farris, A., Attado-Parinello, G., Narcisi, M., and . High-dose folinic acid (FA) and fluorouracil (FU) plus or minus thymostimulin (TS) for treatment of metastatic colorectal cancer: results of a randomized multicenter clinical trial. Anticancer Res 1994;14(2B):617-619. View abstract.

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Palmieri, G., Gridelli, C., Pepe, R., Airoma, G., Iaffaioli, R. V., Frasci, G., Caponigro, F., and Bianco, A. R. Partial response of metastatic hepatocellular carcinoma after treatment with thymostimulin. Tumori 2-28-1990;76(1):61-63. View abstract.

Pandolfi, F., Quinti, I., Montella, F., Voci, M. C., Schipani, A., Urasia, G., and Aiuti, F. T-dependent immunity in aged humans. II. Clinical and immunological evaluation after three months of administering a thymic extract. Thymus 1983;5(3-4):235-240. View abstract.

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Politowski, M., Turowski, G., Nawrocka-Jarosz, B., and Zubel, M. Pre- and postoperative immunologic reactivity of patients with the ischemic disease of lower limbs. The immunostimulating effect of the thymus extract--TFX. Mater.Med Pol. 1979;11(4):339-344. View abstract.

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Sanchiz, F. and Milla, A. A randomised study comparing granulocyte-colony stimulating factor (G-CSF) with G-CSF plus thymostimulin in the treatment of haematological toxicity in patients with advanced breast cancer after high dose mitoxantrone therapy. Eur.J Cancer 1996;32A(1):52-56. View abstract.

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Schuff-Werner, P., Lohr, G., Rauschning, W., Schroder, M., Musil, J., and Nagel, G. A. [Effect of thymostimulin on chemotherapy-induced changes in lymphocyte subset distribution. A longitudinal study in patients with primary inoperable oropharyngeal cancers]. Onkologie. 1987;10(3 Suppl):17-21. View abstract.

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Turowski, G., Sanokowska, E., and Dynowska, D. Trials of thymus extract TFX administration in dermatological patients resistant to conventional treatment methods. Mater.Med Pol. 1988;20(2):128-131. View abstract.

Turowski, G., Urban, A., Cybulski, L., Turaszwili, T., and Zubel, M. Immunological and patho-clinical observations of a patient with rectal carcinoma after long term administration of thymic extract (TFX). Pol.Med Sci Hist Bull. 1976;15(1):51-58. View abstract.

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Velardi, A., Spinozzi, F., Rambotti, P., Tabilio, A., Losito, A., Zampi, I., Cernetti, C., Martelli, M. F., Grignani, F., and Davis, S. The in vivo effect of thymic factor (thymostimulin) administration on circulating immune complexes and serum lysozyme levels in untreated Hodgkin's disease patients. J Clin Oncol. 1983;1(2):117-125. View abstract.

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