Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, , Bioflavonoïde d'Agrumes, Bioflavonoïdes, Bioflavonoids, Blood Orange, Citri Sinensis, Citrus, Citrus aurantium, Citrus aurantium var. dulcis, Citrus aurantium var. sinensis, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoid Extract, Citrus Bioflavonoids, Citrus Extract, Citrus Flavones, Citrus Flavonoids, Citrus macracantha, Citrus Peel Extract, Citrus Seed Extract, Citrus sinensis, Complexe de Bioflavonoïde, Concentré de Bioflavonoïde, Extrait d'Agrume, Extrait de Bioflavonoïde, Extrait de Bioflavonoïde d'Agrumes, Extrait de Zeste d'Agrume, Flavonoïdes d'Agrumes, Flavonoids, Jaffa Orange, Jus d'Orange, Naranja Dulce, Navel Orange, Orange, Orange Bioflavonoids, Orange de Jaffa, Orange de Valence, Orange Douce, Orange Douce Sauvage, Orange Juice, Orange Peel, Orange Sanguine, Pericarpium, Red Orange, Shamouti Orange, Shamouti Sweet Orange, Valencia Orange, Wild Orange, Wild Sweet Orange, Zeste d'Orange, Zeste d'Orange Douce.
Sweet orange is a fruit. The peel and juice are used to make medicine.
甜橙的皮是用于提高appetite; reduce phlegm; and treat coughs, colds, intestinal gas (flatulence), acid indigestion (dyspepsia), and cancerous breast sores. It is also used as a tonic.
Sweet orange juice is used for treating kidney stones (nephrolithiasis) and high cholesterol; and preventing high blood pressure and stroke, as well as prostate cancer.
How does it work?
甜橙中含有大量的维生素C。Some researchers believe sweet orange might help asthma because of the antioxidant activity of vitamin C.
Sweet orange also contains large amounts of potassium. There is evidence that potassium may help prevent high blood pressure and stroke.
Sweet orange fruit and sweet orange juice are used to prevent kidney stones because they contain large amounts of a chemical called citrate. Citrate tends to bind with calcium before it can form kidney stones.
SLIDESHOW
How to Lower Blood Pressure: Exercise TipsSee SlideshowPossibly Effective for...
- Preventing high blood pressure and stroke. Drinking sweet orange juice seems to help lower the risk of high blood pressure and stroke. The U.S. Food and Drug Administration (FDA) allows makers of sweet orange products that provide at least 350 mg of potassium per serving and are low in sodium, saturated fat, and cholesterol to make label claims that their product might reduce the risk of developing high blood pressure and stroke.
- Treating high cholesterol. Drinking sweet orange juice helps improve cholesterol levels. In large amounts (750 mL, or about three 8-oz glasses, per day for four weeks), orange juice seems to increase “good” high-density lipoprotein and reduce the ratio of “bad” low-density lipoprotein (LDL) to HDL cholesterol in people with high cholesterol.
Possibly Ineffective for...
- Preventing prostate cancer.
Insufficient Evidence to Rate Effectiveness for...
- Asthma. There is some evidence that sweet orange and other fruits that are rich in vitamin C might improve lung function in people with asthma. But not all studies agree.
- Colds. Some research shows that drinking 180 mL (about 6 ounces) of sweet orange juice daily might help prevent symptoms of the common cold.
- Kidney stones (nephrolithiasis). Some research reports that drinking 400 mL of sweet orange juice (about 13 ounces) increases the amount of citrate in the urine. This might help to prevent kidney stones that are made of calcium.
- Coughs.
- Eating disorders.
- Cancerous breast sores.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate(detailed description of each of the ratings).
QUESTION
Salt and sodium are the same.See AnswerCeliprolol (Celicard)Interaction Rating:MajorDo not take this combination.
Consuming large amounts of sweet orange juice might decrease how much celiprolol (Celicard) the body absorbs. This might decrease how well celiprolol (Celicard) works. To avoid this interaction, separate taking this medication from consuming sweet orange by at least 4 hours.
IvermectinInteraction Rating:MajorDo not take this combination.
Drinking sweet orange juice might decrease how much ivermectin the body absorbs. Taking sweet orange along with ivermectin might decrease the effectiveness of ivermectin.
Medications moved by pumps in cells (Organic anion-transporting polypeptide substrates)Interaction Rating:MajorDo not take this combination.
Some medications are moved by pumps in cells. Sweet orange might change how these pumps work and decrease how much of some medications get absorbed by the body. This could make these medications less effective. To avoid this interaction, separate taking these medications from consuming sweet orange by at least 4 hours.
Some of these medications that are moved by pumps in cells include bosentan (Tracleer), celiprolol (Celicard, others), etoposide (VePesid), fexofenadine (Allegra), fluoroquinolone antibiotics, glyburide (Micronase,Diabeta), irinotecan (Camptosar), methotrexate,paclitaxel(Taxol), saquinavir (Fortovase,Invirase), rifampin, statins, talinolol, torsemide (Demadex), troglitazone, and valsartan (Diovan).
Pravastatin (Pravachol)Interaction Rating:MajorDo not take this combination.
Drinking sweet orange juice might increase how much pravastatin (Pravachol) the body absorbs. Taking pravastatin (Pravachol) with sweet orange juice might increase drug levels in the body and possibly increase the chance of drug side effects.
Antibiotics (Quinolone antibiotics)Interaction Rating:ModerateBe cautious with this combination.Talk with your health provider.
Calcium-fortified sweet orange juice can reduce the amount of some antibiotics the body absorbs. Reduced absorption of antibiotics can reduce their ability to fight infection. Sweet orange juice without calcium is unlikely to affect quinolone antibiotics.
Some quinolone antibiotics include ciprofloxacin (Cipro), enoxacin (Penetrex),gatifloxacin(Tequin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (Floxin), and trovafloxacin (Trovan).
Fexofenadine (Allegra)Interaction Rating:ModerateBe cautious with this combination.Talk with your health provider.
Sweet orange might decrease how much fexofenadine (Allegra) the body absorbs. Taking sweet orange along with fexofenadine (Allegra) might decrease the effectiveness of fexofenadine (Allegra). To avoid this interaction, separate taking this medication from consuming sweet orange by at least 4 hours.
Medications moved by pumps in cells (P-Glycoprotein substrates)Interaction Rating:ModerateBe cautious with this combination.Talk with your health provider.
Some medications are moved by pumps in cells. Sweet orange might change how these pumps work and change how much of some medications get absorbed by the body. There is not enough information to know how important this interaction might be. Until more is known, sweet orange juice should be used cautiously with medications moved by these pumps.
Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids,erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.
The following doses have been studied in scientific research:
BY MOUTH:
- For high cholesterol: 750 mL sweet orange juice per day.
- For high blood pressure and stroke prevention: Sweet orange juice products that provide at least 350 mg of potassium per serving and are low in sodium, saturated fat, and cholesterol are permitted by the FDA to make labeling claims that they might reduce the risk of developing high blood pressure and stroke.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit theFDA MedWatchwebsite or call 1-800-FDA-1088.
Health SolutionsFrom Our Sponsors
Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55. View abstract.
Baird IM, Hughes RE, Wilson HK, et al. The effects of ascorbic acid and flavonoids on the occurrence of symptoms normally associated with the common cold. Am J Clin Nutr 1979;32:1686-90. View abstract.
Butland BK, Fehily AM, Elwood PC. Diet, lung function, and lung function decline in a cohort of 2512 middle aged men. Thorax 2000;55:102-8. View abstract.
凯里IM, Strachan DP,库克DG。变化的影响in fresh fruit consumption on ventilatory function in healthy British adults. Am J Respir Crit Care Med 1998;158:728-33. View abstract.
FDA, CFSAN. FDA-approved potassium health claim notification for potassium containing foods. 2000. Available at: www.cfsan.fda.gov/~dms/hclm-k.html.
Forastiere F, Pistelli R, Sestini P, et al. Consumption of fresh fruit rich in vitamin C and wheezing symptoms in children. Thorax 2000;55:283-8. View abstract.
Franke AA, Cooney RV, Henning SM, Custer LJ. Bioavailability and antioxidant effects of orange juice components in humans. J Agric Food Chem 2005;53:5170-8. View abstract.
Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49:1403-7. View abstract.
Grossarth-Matichek R, Kiene H, Baumgartner SM, Ziegler R. Use of Iscador, an extract of European mistletoe (Viscum album), in cancer treatment: prospective nonrandomized and randomized matched-pair studies nested within a cohort study. Altern Ther Health Med 2001;7:57-66, 68-72, 74-6 passim. View abstract.
Hatch GE. Asthma, inhaled oxidants, and dietary antioxidants. Am J Clin Nutr 1995;61:625S-30S. View abstract.
Huang SM, Lesko LJ. Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned? J Clin Pharmacol 2004;44:559-69. View abstract.
Ishiwa J, Sato T, Mimaki Y, et al. A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts. J Rheumatol 2000;27:20-5. View abstract.
Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94:233-9. View abstract.
Koitabashi Y, Kumai T, Matsumoto N, et al. Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, in rats and healthy human subjects. Life Sci 2006;78:2852-9. View abstract.
Kurowska EM, Spence JD, Jordan J, et al. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 2000;72:1095-100. View abstract.
Lilja JJ, Juntti-Patinen L, Neuvonen PJ. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther 2004;75:184-90. View abstract.
Moufida S, Marzouk B. Biochemical characterization of blood orange, sweet orange, lemon, bergamot and bitter orange. Phytochemistry 2003;62:1283-9. View abstract.
Odvina CV. Comparative value of orange juice versus lemonade in reducing stone-forming risk. Clin J Am Soc Nephrol 2006;1:1269-74.
Ramos-e-Silva M, da Silva Carneiro SC. Elderly skin and its rejuvenation: products and procedures for the aging skin. J Cosmet Dermatol 2007;6:40-50. View abstract.
Schwartz J, Weiss ST. Relationship between dietary vitamin C intake and pulmonary function in the First National Health and Nutrition Examination Survey (NHANES I). Am J Clin Nutr 1994;59:110-4. View abstract.
Seltzer MA, Low RK, McDonald M, et al. Dietary manipulation with lemonade to treat hypocitraturic calcium nephrolithiasis. J Urol 1996;156:907-9. View abstract.
Stram DO, Hankin JH, Wilkens LR, et al. Prostate cancer incidence and intake of fruits, vegetables and related micronutrients: the multiethnic cohort study. Cancer Causes Control 2006;17:1193-207. View abstract.
Takanaga H, Ohnishi A, Yamada S, et al. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther 2000;293:230-6. View abstract.
Tian R, Koyabu N, Takanaga H, et al. Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates. Pharm Res 2002;19:802-9. View abstract.
Troisi RJ, Willett WC, Weiss ST, et al. A prospective study of diet and adult-onset asthma. Am J Respir Crit Care Med 1995;151:1401-8. View abstract.
Vanapalli SR, Chen Y, Ellingrod VL, et al. Orange juice decreases the oral bioavailability of ivermectin in health volunteers. Clin Pharmacol Ther 2003;73 (Abstract PDII-A-10):P94.