Rebif vs. Gilenya

• Are Rebif and Gilenya the Same Thing?
• What Are Possible Side Effects of Rebif?
• What Are Possible Side Effects of Gilenya?
• What Is Rebif?
• What Is Gilenya?
• What Drugs Interact with Rebif?
• What Drugs Interact with Gilenya?
• How Should Rebif Be Taken?
• How Should Gilenya Be Taken?

Rebif(interferonbeta-1a) andGilenya(fingolimod) are used to treat relapsingmultiple sclerosis(MS).

Rebif and Gilenya belong to different drug classes. Rebif is made from humanproteinsand Gilenya is a sphingosine 1-phosphatereceptormodulator.

Side effectsof Rebif that are different from Gilenya include injection site reactions (pain, swelling, or redness) andflu-like symptoms (such asheadache,dizziness,fatigue,fever,chills,stomach疼痛、流或水stuffy nose, andmuscleaches).

Side effects of Gilenya that are different from Rebif include headache,tiredfeeling,influenza, stuffynose,sinuspain,diarrhea,back pain,livertransaminase elevations, andcough.

Both Rebif and Gilenya may interact withcancermedications andheartorblood pressuremedications.

Rebif may also interact withalcohol,acetaminophen,aspirin,goutorarthritismedication(including gold injections), nonsteroidalanti-inflammatory drugs (NSAIDs), antibiotics,antifungalmedicines, sulfa drugs,tuberculosismedicines,antiviralorHIV/AIDSmedications, medicines to treat mental illness,seizuremedications, birthcontrolpills orhormonereplacementtherapy, anabolic steroids, andcholesterol-lowering medications.

Gilenya may also interact withcitalopram, chlorpromazine,digoxin,erythromycin,haloperidol,ketoconazole, medications to control theimmune system, andmethadone.

Common side effects of Rebif include pain, swelling, or redness at the injection site. Flu-like symptoms such as headache, dizziness, fatigue, fever, chills, stomach pain, runny or stuffy nose, and muscle aches may occur when you first start Rebif. These symptoms usually improve or go away after a few months of continued use of Rebif. Some patients using interferon medications such as Rebif become depressed or havesuicidalthoughts. Tell yourdoctorimmediately if this occurs. Tell your doctor if you have serious side effects of Rebif including:

• mental/mood changes (e.g.,depression的,罕见的想法suicide),
• vision changes,
• gradual changeinweight,
• intolerance to cold or heat,
• increased urination,
• pusor change inskin colorat the injection site,
• signs ofinfection(e.g., fever, persistentsore throat, cough),
• easy bruising or bleeding,
• fast or irregular heartbeat,
• sudden increase in weight,
• swelling hands/legs/feet,
• severe stomach orabdominal pain,
• yellowing eyes orskin, or
• darkurine.

Common side effects of Gilenya include:

• headache,
• tired feeling,
• influenza,
• stuffy nose,
• sinus pain,
• diarrhea,
• back pain,
• liver transaminase elevations, and
• 咳嗽。

Gilenya canaffect你的immunesystem's ability to fight an infection while you are taking the medication and for 2 months after your last dose. Tell your doctor right away if you develop signs of an infection such as:

• persistent cough orsorethroat,
• difficultybreathing,
• fever,
• chills, or
• cold/flu symptoms.

Rebif (interferon beta-1a) Injection is made from human proteins and is used to treat relapsing multiplesclerosis(MS). Rebif will notcureMS; it will only decrease the frequency ofrelapsesymptoms. Common side effects of Rebif include pain, swelling, or redness at the injection site. Flu-like symptoms such as headache, dizziness, fatigue, fever, chills, stomach pain, runny or stuffy nose, and muscle aches may occur when you first start Rebif. These symptoms usually improve or go away after a few months of continued use of Rebif. Some patients using interferon medications such as Rebif become depressed or have suicidal thoughts. Tell your doctor immediately if this occurs.

Gilenya (fingolimod) is a sphingosine 1-phosphate receptor modulator used to treat patients with relapsing forms of multiple sclerosis (MS) to reduce the frequency of exacerbations and to delay physical disability.

Rebif may interact with other drugs. Tell your doctor all medications and supplements you take. Talk to your doctor about how to drink alcohol safely while using this medication. Rebif should not be used duringpregnancy. Talk to your doctor if you arepregnantor think you might become pregnant during treatment. Consult your doctor beforebreastfeeding.

Gilenya may interact with beta-blockers,calciumchannel blockers, citalopram, chlorpromazine, digoxin, erythromycin, haloperidol, ketoconazole, medications to control the immune system, medications for cancer, heart problems, orhigh blood pressure, and methadone. Tell your doctor all medications and supplements you use. Gilenya may cause fetal harm. It takes approximately 2 months for Gilenya to be eliminated from the body. Women should avoid pregnancy during treatment with Gilenya and for 2 months after treatment. It is not known if Gilenya passes intobreast milk. Women and their doctors should decide whether to take Gilenya or breastfeed. Women should not do both.

The recommended dosage of Rebif is 22 mcg to 44 mcg injected subcutaneously three times per week. Rebif is intended for use under the supervision of aphysician. Patients may self-inject only after proper training.

The recommended dose for Gilenya is 0.5mgorally once daily, with or withoutfood.