Dornase alfa

Dornase alfa is a prescription medication used to improve lung function in people with cystic fibrosis.

• Dornase alfa is available under various brand names:Pulmozyme

Common side effects of Dornase alfa include:

• voice alteration;
• sore throat;
• rash;
• laryngitis;
• eye redness, irritation, or inflammation; or
• nasalstuffiness ordischarge.

Serious side effects of Dornase alfa include:

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
• increased difficulty breathing;
• chest pain; or
• fever.

Rare side effects of Dornase alfa include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
• Serious eye symptoms such as sudden vision loss, blurred vision,tunnel vision, eye pain or swelling, or seeing halos around lights.
• Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Solution, inhalation

• 1 mg/mL (2.5mL)

Cystic Fibrosis

Adult and pediatric dosage

• 2.5 mg vianebulizerevery day; some patients may benefit from twice-daily administration

Dosage Considerations – Should be Given as Follows:

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

• Dornase alfa has no noted severe interactions with any other drugs.
• Dornase alfa has no noted serious interactions with any other drugs.
• Dornase alfa has no noted moderate interactions with any other drugs.
• Dornase alfa has no noted minor interactions with any other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Allergic reaction to dornase alfa or to other Chinese Hamster Ovary cell products

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Dornase alfa?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Dornase alfa?”

Cautions

• 不要稀释或混合dornase阿尔法解智慧h any other drugs in the nebulizer. Mixing of dornase alfa with other drugs could lead to changes in the actions of the medications.
• Ampules of dornase alfa do not contain a preservative. Once opened, the entire contents of the ampule must be used or discarded.
• Dornase alfa must be stored in the refrigerator between 36 and 46 degreesFahrenheit(2 and 8 degrees Celsius) and protected from strong light. Keep unused ampules in the protective foil pouch. Dornase alfa should be kept refrigerated during transport. Combined lengths of exposure of the medication to room temperature should not exceed 24 hours.
• 不要稀释或混合dornase阿尔法解智慧h any other drugs in the nebulizer. Mixing of dornase alfa with other drugs could lead to changes in the actions of the medications.

Pregnancy and Lactation

• Dornase alfa is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Lactation

• It is not known whether dornase alfa passes into breast milk. Do not use dornase alfa without first talking to your doctor if you are breastfeeding a baby.