Protonix vs. Zantac

Protonix(pantoprazolesodium) andZantac(ranitidinehydrochloride) are used to treatgastroesophageal refluxdisease(GERD) and erosiveesophagitis.

Zantac is also used for treatingheartburnandZollinger-Ellison syndrome.

Protonix and Zantac belong to different drug classes. Protonix is a proton pump inhibitor (PPI) and Zantac is a H2 (histamine-2)receptorblocker.

Protonix is available byprescriptionwhile Zantac is availableover-the-counter(OTC) and as ageneric.

Side effectsof Protonix include:

• injection site reactions (redness,pain, swelling),
• headache,
• nausea,
• vomiting,
• abdominalorstomachpain,
• diarrhea,
• gas,
• dizziness,
• jointpain,
• weight changes,
• drowsiness,
• tiredfeeling, or
• sleepproblems (insomnia).

Common side effects of Zantac include:

• constipation,
• diarrhea,
• fatigue,
• headache (may be severe),
• drowsiness,
• dizziness,
• sleep problems (insomnia),
• decreased sex drive,
• impotence,
• difficulty having anorgasm,
• musclepain,
• stomach pain,
• nausea,
• vomiting,
• diarrhea,
• constipation,
• or swollen or tender breasts (inmen).

What is Zantac?

Zantac (ranitidine hydrochloride) is a H2 (histamine-2) receptor blocker used for treating and preventing ulcers in theduodenumand stomach. Zantac is also used for treating:

• heartburn,
• erosive esophagitis,
• and Zollinger Ellison并发症状.

Protonix may interact with atazanavir,bloodthinners,digoxin,diuretics(waterpills),ketoconazole, ormethotrexate.

Protonix may also interact with nelfinavir,ampicillin, oriron.

Zantac may interact with ketoconazole, atazanavir, and blood thinners such aswarfarin.

Zantac may also interact with triazolam, procainamide, riazolam, midazolam,glipizide, delavirdine, and gefitinib.

The recommended adult dose of Protonix is 40mgonce daily.

• ProtonixOralSuspension should be taken 30 minutes before a meal
• Protonix Oral Suspension should only be taken with applesauce or apple juice 30 minutes before a meal.
• Protonix Oral Suspension should not be taken in or with water or other liquids, or with other foods.
• Protonix Oral Suspension should not be chewed or crushed.
• Protonix Oral Suspension packet should not be divided to make a smaller dose.

Zantac is available intablet, syrup, and injectable formulations.

• adults and children 12 years and over:
  • torelievesymptoms, swallow 1 tablet with a glass of water
  • topreventsymptoms, swallow 1 tablet with a glass of water30 to 60 minutes beforeeatingfoodor drinking beverages that cause heartburn
  • can be used up to twice daily (do not take more than 2 tablets in 24 hours)
• children under 12 years: ask adoctor

Other Information

• 不要使用如果瓶盖下印箔是开放的吗n or torn (bottles)
• do not use if individualblisterunit is open or torn (blisters)
• do not use if individual foil packet is open or torn (pouch)
• store at 20°-25°C (68°-77°F)
• avoid excessive heat or humidity
• this product is sodium and sugar free