Prolia vs. Tymlos

• Are Prolia and Tymlos the Same Thing?
• What Are Possible Side Effects of Prolia?
• What Are Possible Side Effects of Tymlos?
• What is Prolia?
• What is Tymlos?
• What Drugs Interact with Prolia?
• What Drugs Interact with Tymlos?
• How Should Prolia Be Taken?
• How Should Tymlos Be Taken?

Prolia(denosumab) andTymlos(abaloparatide) injection are used to treatboneloss (osteoporosis)inwomen who are at high risk for bonefractureaftermenopause.

Prolia and Tymlos belong to different drug classes. Prolia is amonoclonal antibodyand Tymlos injection is a humanparathyroid hormonerelatedpeptide[PTHrP(1-34)]analog.

Commonside effectsof Prolia include:

• lowcalciumlevels (especially if you havekidneyproblems),
• weakness,
• constipation,
• back pain,
• musclepain,
• pain in yourarmsand legs,
• anemia,
• diarrhea, or
• skinproblems (eczema, blisters,dry skin、脱皮、红肿,itching, smallbumps).

You may also be more likely to get a seriousinfection, such as a skin,ear,stomach/gut, orbladder infectionwhile taking Prolia. Tell yourdoctorif you develop signs of infection, such as:

• fever/chills,night sweats,
• red/swollen/tender/warm skin (with or withoutpus),
• severe stomach orabdominal pain,
• ear pain or drainage, trouble hearing,
• frequent/painful/burning urination, or
• pink/bloodyurine.
• severe itching, burning, rask, blistering, peeling, or dryness of the skin,
• cough,
• shortness of breath,
• pinpoint purple or red spots under your skin,
• flusymptoms, or
• weight loss.

Tell your doctor if your experience serious side effects of Prolia includingjaw痛苦,新的或新近出版的sualthigh/hip/groinpain, or bone/joint/muscle pain.

Common side effects of Tymlos include:

• high calcium levels in the urine (hypercalciuria),
• dizziness,
• nausea,
• headache,
• palpitations,
• fatigue,
• 上abdominalpain and
• spinningsensation(vertigo).

Prolia (denosumab) is amonoclonalantibodyused to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause.

Tymlos (abaloparatide) injection is a human parathyroidhormonerelated peptide [PTHrP(1-34)] analog indicated for the treatment ofpostmenopausalwomen with osteoporosis at high risk for fracture.

Prolia may interact with steroids orcancermedicine,cyclosporine,sirolimus, tacrolimus, basiliximab,muromonab-CD3,mycophenolatemofetil,azathioprine,leflunomide, or etanercept.

Tymlos may interact with other drugs. Tell your doctor all medications and supplements you use.

Prolia should be administered by a doctor. The recommended dose of Prolia is 60mgadministered as a singlesubcutaneous(under the skin) injection once every 6 months.

The recommended dose of Tymlos is 80 mcg subcutaneously once daily; patients should receive supplemental calcium and维生素Dif dietary intake is inadequate.