Orencia vs. Hadlima

Orencia(abatacept) andHadlima(adalimumab-bwwd) are indicated for treatment ofrheumatoid arthritis(RA).

Hadlima is also used to treatjuvenileidiopathicarthritis(JIA),psoriatic arthritis(PsA),ankylosing spondylitis(AS), adultCrohn's disease(CD),ulcerative colitis(UC), andplaque psoriasis(Ps).

Hadlima is biosimilar toHumira(adalimumab).

Orencia and Hadlima belong to different drug classes. Hadlima is atumor necrosis factor(TNF) blocker and Orencia is arecombinantDNA生成的傅sionprotein.

Side effectsof Orencia that are different from Hadlima includenausea,diarrhea,stomachpain, indigestion,dizziness, flushing,back pain, and cold symptoms such as stuffy head/nose, sneezing,sore throat, orcough.

Side effects of Orencia and Hadlima that are similar includeheadache.

Side effects of Hadlima that are different from Orencia include infections (e.g. upperrespiratorytract,sinusitis), injection site reactions (redness,itching, bleeding, pain, and swelling), andrash.

Both Orencia around Hadlima may interact with anakinra and livevaccines.

Orencia may also interact with adalimumab, certolizumab, etanercept, golimumab,英夫利昔单抗,rituximab, and tocilizumab.

Hadlima may also interact with abatacept,warfarin,cyclosporine, andtheophylline.

Side effects of Orencia include:

• headache,
• nausea,
• diarrhea,
• stomach pain,
• indigestion,
• dizziness,
• flushing,
• back pain, or
• cold symptoms such as stuffy head/nose, sneezing,sorethroat, or cough.

Serious side effects of Orencia include:

• fever,
• chills,
• night sweats,
• flusymptoms,
• weight loss,
• feeling verytired,
• 致命的感染,
• shortness of breath,
• changesinthe amount ofurine,
• pain when urinating, and
• severeabdominal pain.

Common side effects of Hadlima include:

• infections (e.g. upper respiratory tract, sinusitis),
• injection site reactions (redness, itching, bleeding, pain, and swelling),
• headache, and
• rash

Orencia (abatacept) is a recombinant DNA generated fusion protein used to treat the symptoms of rheumatoid arthritis and to preventjointdamage caused by these conditions. Orencia is also used to treatarthritis in childrenwho are at least 6 years old. Orencia is not a治愈for anyautoimmunedisorder and only treats symptoms.

Hadlima (adalimumab-bwwd) is atumornecrosisfactor (TNF) blocker indicated for treatment of rheumatoid Arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PsA),ankylosingspondylitis(AS), adult Crohn'sdisease(CD), ulcerativecolitis(UC), andplaquepsoriasis(Ps). Hadlima is biosimilar to Orencia (adalimumab).

There may be other drugs that can interact with Orencia. The prescribingdoctorneeds to know all medications (including herbals) that the person is taking. Duringpregnancy, Orencia should be used only when prescribed. It is unknown if Orencia passes intobreast milkor if it would harm anursingbaby.Breastfeedingis not recommended while using this drug.

Hadlima may interact with abatacept, anakinra, warfarin, cyclosporine, theophylline, and live vaccines.

Orencia is supplied in single use vials at a strength of 250mg per vial. Orencia is administered intravenously (IV) as a 30-minute infusion. Dosing is based on thepatient's weight. Following the initialintravenousadministration, an IV infusion is given at 2 and 4 weeks after the first infusion and every 4 weeks thereafter.

The dose of Orencia to treat adult rheumatoid arthritis and psoriatic arthritis is 50mgonce weekly with or withoutmethotrexate(MTX). The dose of Orencia to treat ankylosing spondylitis is 50 mg once weekly. The dose of Orencia to treat adult plaque psoriasis is 50 mg twice weekly for 3 months, followed by 50 mg once weekly. The dose of Orencia to treatpediatricplaque psoriasis or plaque psoriasis (patients who weigh 63 kg or more) is 50 mg once weekly.