Nourianz vs. Mirapex

Nourianz(istradefylline) andMirapex(pramipexole) are used to treat different aspects of帕金森病.

Nourianz is indicated as adjunctive treatment to levodopa/carbidopainadult patients with Parkinson'sdiseaseexperiencing "off" episodes.

Mirapex is used to treat symptoms of Parkinson's disease andrestless legssyndrome(RLS).

Nourianz and Mirapex belong to different drug classes. Nourianz is anadenosinereceptorantagonistand Mirapex is adopamineagonist.

Side effectsof Nourianz and Mirapex that are similar includedizziness,constipation,nausea, andsleepproblems (insomniaor unusualdreams).

Side effects of Nourianz that are different from Mirapex includeinvoluntarymusclemovements and hallucinations.

Side effects of Mirapex that are different from Nourianz include dizziness on standing,dry mouth,stomachpain, vomiting,headache, spinningsensation(vertigo), drowsiness, swelling in your hands andfeet, appetite or weight changes,blurred vision,memoryproblems or forgetfulness, confusion or thinking problems, swelling in your hands or feet,impotence, loss of interest in sex, and trouble having anorgasm.

Both Nourianz and Mirapex may interact withseizure medications.

Nourianz may also interact with itraconazole,ketoconazole,clarithromycin,rifampin, St. John's wort, midazolam,atorvastatin, anddigoxin.

Mirapex may also interact with other drugs that make you drowsy (narcotics, sleeping pills, muscle relaxers, oranxietymedications),cimetidine,metoclopramide, and medicines to treat mental illness.

Common side effects of Nourianz include:

• involuntary muscle movements,
• dizziness,
• constipation,
• nausea,
• hallucinations, and
• insomnia

Common side effects of Mirapex include:

• unusual or unpleasant味道in yourmouth,
• discomfort in thenoseorthroatafter using thenasalspray,
• warmth/redness/tingling/numbness under theskin,
• nausea,
• dry mouth,
• weakness,
• drowsiness,
• dizziness, or
• pressure or heavy feeling in any part of your body

Nourianz (istradefylline) is an adenosine receptor antagonist indicated as adjunctive treatment to levodopa/carbidopa in adult patients with Parkinson's disease (PD) experiencing "off" episodes.

Mirapex (zolmitriptan) Nasal Spray is a headache medicine that narrowsbloodvessels around thebrainused to treatmigraineheadaches. Mirapex Nasal Spray will only treat a headache that has already begun. Mirapex Nasal Spray will not prevent headaches or reduce the number of attacks.

Nourianz may interact with itraconazole, ketoconazole, clarithromycin,carbamazepine, rifampin,phenytoin, St. John's wort, midazolam, atorvastatin, and digoxin. Nourianz is not recommended for use duringpregnancy; it may harm afetus. Women of childbearing potential are advised to use contraception during treatment with Nourianz. It is unknown if Nourianz passes intobreast milkor how it wouldaffectanursinginfant. Consult yourdoctorbeforebreastfeeding.

Mirapex may interact with othermigraine headachemedicines, cimetidine, orantidepressants. Tell your doctor all medications you are taking. During pregnancy, Mirapex should be used only when prescribed. It is unknown if this drug passes intobreastmilk. Consult your doctor before breast-feeding.

Mirapex may also interact withalcohol,oralcontraceptives, and carbonic anhydrase inhibitors.

努美阿的推荐剂量rianz is 20mgorally once daily. The dosage may be increased to a maximum of 40 mg once daily.

The initial dose of Mirapex is 2.5 mg or less. The dose can be repeated after 2 hours if symptoms persist. The maximum dose is 10 mg per day.