Major depression:Adiseasewith certain characteristic signs and symptoms that interferes with the ability to work, sleep, eat, and enjoy once pleasurable activities.
The characteristic signs and symptoms ofmajordepression include loss of interestinactivities that were once interesting or enjoyable, including sex; loss of appetite (anorexia) with weight loss or overeating with weight gain; loss of emotional expression (flat affect);情绪持续悲伤、焦虑或空;感觉ings of hopelessness, pessimism, guilt, worthlessness, or helplessness; social withdrawal; unusual fatigue, low energy level, a feeling of being slowed down;sleepdisturbance with insomnia, early-morning awakening, or oversleeping; trouble concentrating, remembering, or making decisions; unusual restlessness or irritability; persistent physical problems such as headaches, digestive disorders, or chronic pain that do not respond to treatment; thoughts ofdeathor suicide or suicide attempts.Alcoholor drug abuse may be signs ofdepression.
Disabling episodes of majordepressioncan occur once or a number of times in a lifetime.
For more information, see Depression.
