How Do Alpha-2 Adrenergic Agonists Work?

Alpha-2 adrenergic agonists are drugs used to treat注意力缺陷hyperactivity disorder(ADHD),high blood pressure, andmusclespasticity与multiple sclerosisandspinal cord injury. Alpha-2 adrenergic agonists stimulate alpha-2 adrenergic receptorsinthecentral nervous systemand decreasesympathetic nervous systemactivity. Alpha-2 receptors are found on cells in the sympathetic nervous system. The sympathetic nervous system is the part of the nervous system that produces fight-or-flight response and increasesheart rate,blood pressure,breathingrate, andpupilsize.

Alpha-2 adrenergic agonists are used to treat:

• ADHD
• Muscle spasticity
• Cramps and tightening of the muscles
• Hypertension(highbloodpressure)

Side effects of alpha-2 adrenergic agonists include:

• Dizziness
• Lightheadedness
• Headache
• Tiredness
• Sleeplessness
• Nauseaand vomiting
• Constipation
• Abdominaldiscomfort
• Decreased appetite
• Syncope
• Bradycardia(lowheartrate)
• Hypotension(low blood pressure)
• Yellowing ofskinor eyes
• Increased bruising and bleeding
• Dry mouth
• Mood disorders
• Anxiety
• Blurred vision
• Anaphylaxis(life-threatening allergic reactions)

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with yourdoctororpharmacistto make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking yourmedicationand never change your dose or frequency without consulting your doctor.

Genericand brand names of alpha-2 adrenergic agonists include:

• Guanfacine(Intuniv,Tenex)
• Tizanidine(Zanaflex)