Granulocytopenia:A marked decrease in the number of granulocytes. Granulocytes are a type of white blood cell filled with microscopic granules that are little sacs containing enzymes that digest microorganisms.
Granulocytes are part of the innate, somewhat non specific infection-fightingimmune system. They do not respond exclusively to specific antigens, as do B-cells and T-cells.
Granulocytopenia或者,它也被称为,agranulocytosisresults in a syndrome of frequent chronic bacterial infections of the skin,lungs, throat etc. Although "agranulocytosis" literally means no granulocytes, there may, in fact, be some granulocytes but too few of them, i.e. granulocytopenia. Granulocytopenia can be genetic and inherited or it can beacquiredas, for example, an aspect of白血病.
Neutrophils, eosinophils and basophils are all types of granulocytes. They are named by the staining features of their granules in the laboratory:
- Neutrophils have "neutral" subtle granules;
- Eosinophils have prominent granules that stain readily with the acid dye eosin; and
- Basophils have prominent granules that stain readily basic (non acidic) dyes.
This classification dates back to a time when certain structures could be identified in cells by histochemistry, but the functions of these intracellular structures were still not yet fathomed. However, the classification of granulocytes into neutrophils, eosinophils and basophils is still widely used (and quite useful).
Granulocytopenia can therefore more specifically involveneutropenia(shortage of neutrophils), eosinopenia and/or basopenia. The term "neutropenia" is sometimes used interchangeably with granulocytopenia or agranulocytosis.
