Acide Gammalinolénique, Acide Gamma-Linolénique, Ácido Gama Linolénico, AGL, Gamolenic Acid, GLA, Gammalinolenic Acid, Gamma-Linolenic Acid, (Z,Z,Z)-Octadeca-6,9,12-trienoic acid.
Gamma linolenic acid is a fatty substance found in various plant seed oils such as borage oil and evening primrose oil. People use it as medicine.
Gamma linolenic acid (GLA) is used for conditions that affect the skin including systemicsclerosis,psoriasis, andeczema. It is also used forrheumatoid arthritis(RA), polyps in the mouth, highcholesteroland other blood fats,heart disease,代谢综合征(Syndrome-X), diabetic nerve pain, attention deficit-hyperactivitydisorder (ADHD), depression, depression after childbirth, chronic fatigue syndrome (CFS), andhay fever(allergic rhinitis). Some people use it to prevent cancer and to helpbreast cancerpatients respond faster to treatment with the drugtamoxifen.
How does it work?
Gamma linolenic acid is an omega-6 fatty acid, which the body can convert to substances that reduce inflammation and cell growth.
SLIDESHOW
What Is Rheumatoid Arthritis (RA)? Symptoms, Treatment, DiagnosisSee SlideshowPossibly Effective for...
- Nerve problems due to diabetes (diabetic neuropathy). Taking gamma linolenic acid by mouth for 6-12 months seems to reduce symptoms and prevent nerve damage in people with nerve pain due to type 1 ortype 2 diabetes. Gamma linolenic acid seems to work better in people with good blood sugar control.
Possibly Ineffective for...
- Allergic skin conditions (eczema). Some early research suggests that taking gamma linolenic acid by mouth for 4 weeks might improve symptoms in children with allergic skin conditions such as itching and redness. However, combined results from 11 studies show that gamma linolenic acid from borage oil or evening primrose oil does not improve allergic skin conditions.
- Scleroderma, a condition in which skin hardens. Some research suggests that taking gamma linolenic acid by mouth does not reduce symptoms ofscleroderma.
- Ulcerative colitis. Some research suggests that taking a combination of gamma linolenic acid, eicosapentaenoic acid (EPA), anddocosahexaenoic acid(DHA) for 12 months does not reduce symptoms ofulcerative colitis.
Insufficient Evidence to Rate Effectiveness for...
- Breast cancer. Early research suggests that taking gamma linolenic acid improves the response to tamoxifen in people with breast cancer.
- High blood pressure. Some research shows that taking gamma linolenic acid with eicosapentaenoic acid (EPA) does not decrease modestlyhigh blood pressure. However, other research shows that taking gamma linolenic acid, EPA, and docosahexaenoic acid (DHA) for 6 weeks may decreasediastolic(the bottom number) blood pressure.
- Oral polyps.
- High cholesterol.
- Heart disease.
- Cancer prevention.
- Attention deficit-hyperactivity disorder (ADHD).
- Depression.
- Chronic fatigue syndrome.
- Hay fever.
- Psoriasis.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate(detailed description of each of the ratings).
Gamma linolenic acid isPOSSIBLY SAFEfor most adults when taken by mouth in amounts of no more than 2.8 grams per day for up to a year. It can cause digestive-tract side effects, such as soft stools, diarrhea,belching, and intestinal gas. It can also make blood take longer to clot.
QUESTION
The termarthritisrefers to stiffness in the joints.See AnswerBleeding disorders: Gamma linolenic acid might slow blood clotting. There is some concern that it might increase the risk of bruising and bleeding in people with bleeding disorders.
Surgery: Since gamma linolenic acid might slow blood clotting, there is concern that it might increase the risk of extra bleeding during and after surgery. Stop taking gamma linolenic acid at least 2 weeks before a scheduled surgery.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating:ModerateBe cautious with this combination.Talk with your health provider.
Gamma linolenic acid might slow blood clotting. Taking gamma linolenic acid along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting includeaspirin, clopidogrel (Plavix), diclofenac (Voltaren,Cataflam, others),ibuprofen(Advil, Motrin, others), naproxen (Anaprox,Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox),heparin, warfarin (Coumadin), and others.
PhenothiazinesInteraction Rating:ModerateBe cautious with this combination.Talk with your health provider.
Taking gamma linolenic acid with phenothiazines might increase the risk of having aseizurein some people.
Some phenothiazines include chlorpromazine (Thorazine), fluphenazine (Prolixin), trifluoperazine (Stelazine),甲硫哒嗪(Mellaril), and others.
The following doses have been studied in scientific research:
BY MOUTH:
- For nerve pain due todiabetes: 360 to 480 mg of gamma linolenic acid per day.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit theFDA MedWatchwebsite or call 1-800-FDA-1088.
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