Fosamax vs. Prolia

• Are Fosamax and Prolia the Same Thing?
• What Are Possible Side Effects of Fosamax?
• What Are Possible Side Effects of Prolia?
• What is Fosamax?
• What is Prolia?
• What Drugs Interact with Fosamax?
• What Drugs Interact with Prolia?
• How Should Fosamax Be Taken?
• How Should Prolia Be Taken?

Fosamax(alendronatesodium) andProlia(denosumab) are used to treat and preventosteoporosis.

Fosamax is also used to treat Paget'sdisease.

Fosamax and Prolia belong to different drug classes. Fosamax is abisphosphonateand Prolia is amonoclonal antibody.

Commonside effectsof Fosamax include:

• gas,
• constipation,
• heartburn,
• diarrhea,
• bloating,
• nausea,
• vomiting,
• stomachpain,
• jointpain or swelling,
• swellinginyour hands orfeet,
• dizziness,
• headache,
• eyepain,
• back pain, or
• weakness.

Serious side effects of Fosamax include:

• severe pain (joints,bone,muscle,jaw, back or heartburn),
• chest pain,
• difficulty swallowing,
• bloody stools,
• eye pain,
• skinblisters, and
• swelling of the face,tongue, orthroat.

Common side effects of Prolia include:

• lowcalciumlevels (especially if you havekidneyproblems),
• weakness,
• constipation,
• back pain,
• muscle pain,
• pain in yourarmsand legs,
• anemia,
• diarrhea, or
• skin problems (eczema, blisters,dry skin, peeling, redness,itching, smallbumps).

You may also be more likely to get a seriousinfection, such as a skin,ear, stomach/gut, orbladder infectionwhile taking Prolia. Tell yourdoctorif you develop signs of infection, such as:

• fever/chills,night sweats,
• red/swollen/tender/warm skin (with or withoutpus),
• severe stomach orabdominal pain,
• ear pain or drainage, trouble hearing,
• frequent/painful/burning urination, or
• pink/bloodyurine.
• severe itching, burning, rask, blistering, peeling, or dryness of the skin,
• cough,
• shortness of breath,
• pinpoint purple or red spots under your skin,
• flusymptoms, or
• weight loss.

告诉你的医生如果你的经历严重的effects of Prolia including jaw pain, new or unusualthigh/hip/groinpain, or bone/joint/muscle pain.

Fosamax (alendronate sodium) is a bisphosphonate that is a specific inhibitor ofosteoclast-mediated boneresorptionused to both treat and prevent osteoporosis, and to treat Paget's disease.

Prolia (denosumab) is amonoclonalantibodyused to treat bone loss (osteoporosis) in women who are at high risk for bonefractureaftermenopause.

Fosamax may interact withaspirinor otherNSAIDs(non-steroidalanti-inflammatory drugs).

Prolia may interact with steroids orcancermedicine,cyclosporine,sirolimus, tacrolimus, basiliximab,muromonab-CD3,mycophenolatemofetil,azathioprine,leflunomide, or etanercept.

Fosamax is available in atabletororalliquid form. Each bottle of the oral solution contains 91.35mgof alendronate monosodiumsalttrihydrate, which is themolarequivalent to 70 mg of the drug. The recommended initial dosage is one 70 mg molar equivalent tablet or oral liquid bottle once weekly or one 10 mg molar equivalent tablet per day. Fosamax must be taken at least one-half hour before the firstfood, beverage, ormedicationof the day with plainwateronly to avoid any reduction ingastrointestinaladsorption.

Prolia should be administered by a doctor. The recommended dose of Prolia is 60 mg administered as a singlesubcutaneous(under the skin) injection once every 6 months.