How Do Dopamine/Norepinephrine Reuptake Inhibitors Work?
Dopamine/去甲肾上腺素reuptakeinhibitors are medications prescribed to improve wakefulness and alertnessinpeople who feel excessively drowsy during the day because ofsleep disordersthataffectrestfulsleepduring the night.
Dopamine and norepinephrine reuptake inhibitors work by increasing the levels of dopamine and norepinephrine, two of the chemicals (neurotransmitters) released bynervecells (neurons) to communicate with each other.
Dopamine has many functions that include regulation of the sleep-wake cycle, while norepinephrine regulatesattention, arousal andstressreactions. Increase in the concentration of dopamine and norepinephrine in thebrainimproves wakefulness and energy.
Neurotransmitters are naturally broken down and reabsorbed by neurons after neurotransmission is completed. Dopamine and norepinephrine reuptake inhibitors increaseneurotransmitterlevels in the brain by preventing their再吸收(reuptake).
How Are Dopamine/Norepinephrine Reuptake Inhibitors Used?
Dopamine/norepinephrine reuptake inhibitors areoraltablets used to improve wakefulness in adults with过度daytime sleepinessassociated with:
- Narcolepsy:Achronicneurologicalsleep disorderthat affects the ability of the brain to regulate the sleep-wake cycle.
- Obstructive sleep apnea:A disorder that causes repetitive episodes ofobstructionor decrease of airflow inbreathingwhile asleep, due to narrowing or blocking of the upperrespiratorytract.
What Are Side Effects of Dopamine/Norepinephrine Reuptake Inhibitors?
Side effects of dopamine/norepinephrine reuptake inhibitors may include the following:
- Headache
- Decreased appetite
- Nausea
- Anxiety
- Insomnia
- Dry mouth
- Constipation
- Diarrhea
- Abdominal pain
- Vomiting
- Palpitations
- 胸部discomfort
- 胸部pain
- Dizziness
- Agitation
- Irritability
- Disturbances in attention
- Tremor
- Bruxism(teeth grinding)
- Cough
- Dyspnea(shortness of breath)
- Hyperhidrosis(excessivesweating)
- Feeling jittery
- Restlessness
- Thirst
- Decrease in weight
Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with yourdoctororpharmacistto make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking yourmedicationand never change your dose or frequency without consulting your doctor.
