HOW DO DECARBOXYLASE INHIBITORS WORK?
Decarboxylase inhibitors are a class of medications used to treat symptoms of Parkinson’sdisease.
The direct cause of Parkinson's disease or Parkinsonian-likesyndromeis the deficiency of theneurotransmitterdopamineinthebrain. Antiparkinson medications aim to prolong the action of dopamine in the brain by:
- Replacing dopamine
- Inhibiting dopamine breakdown
- Sensitizing dopamine receptors to stimulate dopamine release
Decarboxylase is anenzymethat initiates the breakdown of levodopa after exerting its effect. Decarboxylase inhibitors block the action of decarboxylase, thereby preventing the breakdown of levodopa, which in turn, increases the availability of levodopa at theblood-brain barrier, thus allowing a lower dose of levodopa. Levodopa gets converted into dopamine in the brain and restores the depleted dopamine levels.
HOW ARE DECARBOXYLASE INHIBITORS USED?
Decarboxylase inhibitors can be used alone or as a combination with other drugs to treat Parkinson's disease and its symptoms.
WHAT ARE SIDE EFFECTS OF DECARBOXYLASE INHIBITORS?
Some of the side effects of decarboxylase inhibitors include:
- Swelling
- Agitation
- Anxiety
- Ataxia(loss ofcontrolof movements)
- Bruxism(teeth grinding)
- Confusion
- Daytime sleepiness
- Decreasedattentionspan
- Dyskinesia(uncontrolled,involuntarymovements)
- Dystonia
- Euphoria
- Insomnia
- Fainting
- Fatigue
- Increased trembling of hands
- Insouciance (indifference)
- 内存loss
- Nightmares
- Nervousness
- Restlessness
- Trismus(spasmofjawmuscles, causing themouthto remain tightly closed)
- Vividdreams
- Alopecia
- Hot flashes
- Increased or darksweating
- Skineruptions
- Abdominal painand discomfort
- Burning feeling in thetongue
- Constipation
- Diarrhea
- Dysgeusia(impairment in thesenseof味道)
- Dry mouth
- Nausea
- Weight loss
- Darkurine
The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with yourdoctoror药剂师to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking yourmedicationand never change your dose or frequency without consulting your doctor.
