Cymbalta vs. Wellbutrin

• Are Cymbalta and Wellbutrin the Same Thing?
• What Are Possible Side Effects of Cymbalta?
• What Are Possible Side Effects of Wellbutrin?
• What is Cymbalta?
• What is Wellbutrin?
• What Drugs Interact with Cymbalta?
• What Drugs Interact with Wellbutrin?
• How Should Cymbalta Be Taken?
• How Should Wellbutrin Be Taken?

Cymbalta(duloxetine) andWellbutrin(bupropion) areantidepressantsused for treatingdepression.

Cymbalta is also used to treatanxiety disorder, andpainassociated with diabeticperipheral neuropathyorfibromyalgia. Wellbutrin is also used to treatseasonal affective disorder.

Commonside effectsof Cymbalta include:

• nausea,
• dry mouth,
• constipation,
• diarrhea,
• fatigue,
• tiredfeeling,
• drowsiness,
• difficulty sleeping,
• loss of appetite, and
• dizziness.

Common side effects of Wellbutrin include:

• agitation,
• drymouth,
• insomnia,
• headache,
• nausea,
• vomiting,
• constipation,
• stomachpain,
• dizziness,
• ringing in the ears,
• vision problems orblurred vision,
• loss of interestinsex,
• sore throat,
• musclepain,
• itchingorskinrash,
• increasedsweating,
• increased urination,
• tremor,
• changes in appetite,
• weight lossor gain,
• jointaches,
• strangetastein the mouth,
• diarrhea, and
• seizures (especially at higher doses).

Cymbalta is aprescription药用于治疗某种泰pe of depression calledMajorDepressive Disorder (MDD). Cymbalta belongs to a class of medicines known as SNRIs (orserotonin-去甲肾上腺素reuptakeinhibitors).

Cymbalta is also used to treat or manage:

• Generalized Anxiety Disorder(GAD)
• DiabeticPeripheralNeuropathic Pain(DPNP)
• Fibromyalgia (FM)
• ChronicMusculoskeletal Pain

Wellbutrin is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder.

Do Not take Cymbalta if you:

• take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider orpharmacistif you are not sure if you take anMAOI, including theantibioticlinezolidorintravenousmethylene blue.
• Do not take an MAOI within 5 days of stopping Cymbalta unless directed to do so by your healthcare provider.
• Do not start Cymbalta if you stopped taking an MAOI in the last 14 days unless directed to do so by your healthcare provider.

Tell your healthcare provider about all the medicines that you take,including prescription andover-the-countermedicines,vitamins, andherbalsupplements. Cymbalta and some medicines may interact with each other, may not work as well, or may cause serious side effects.

Especially tell your healthcare provider if you take:

• triptans used to treatmigraine headache
• medicines used to treat mood,anxiety, psychotic or thought disorders, including tricyclics,lithium, buspirone, SSRIs, SNRIs or MAOIs
• tramadoland fentanyl
• amphetamines
• cimetidine
• the antibioticsciprofloxacin, enoxacin
• medicine to treat irregularheart rate(likepropafenone,flecainide, quinidine)
• theophylline
• thebloodthinnerwarfarin(Coumadin,Jantoven)
• non-steroidalanti-inflammatory drug (NSAID) (likeibuprofen,naproxenoraspirin）.
• over-the-counter supplements such astryptophanor St. John's Wort
• thioridazine(梅尔laril）.梅尔laril together with Cymbalta can cause seriousheartrhythm problems or suddendeath.

Ask your healthcare provider for a list of these medicines if you are not sure.

Do not take Cymbalta with any other medicine that contain duloxetine.

Do not take Wellbutrin if you:

• have or had aseizuredisorder orepilepsy.
• are takingZyban(used to help people stop smoking) or any other medicines that contain bupropion hydrochloride, such asWellbutrin SRSustained-Release Tablets orWellbutrin XLExtended-Release Tablets. Bupropion is the same ingredient that is in Wellbutrin.
• drink a lot ofalcoholand abruptly stop drinking, or use medicines called sedatives (these make you sleepy) orbenzodiazepinesand you stop using them all of a sudden.
• have taken within the last 14 days medicine for depression called amonoamine oxidase inhibitor(MAOI), such asNardil(phenelzine sulfate),Parnate(tranylcypromine sulfate), orMarplan(isocarboxazid).
• have or had an eating disorder such asanorexia nervosaorbulimia.
• are allergic to the active ingredient in Wellbutrin, bupropion, or to any of the inactive ingredients. See the end of this leaflet for a complete list of ingredients in Wellbutrin.

Take Cymbalta exactly as your healthcare provider tells you to take it. Your healthcare provider may need to change the dose of Cymbalta until it is the right dose for you.

Swallow Cymbalta whole. Do not chew or crush Cymbalta.

Do not open thecapsuleand sprinkle onfoodor mix with liquids. Opening the capsule mayaffecthow well Cymbalta works.

Cymbalta may be taken with or without food.

If you miss a dose of Cymbalta, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Cymbalta at the same time.

If you take too much Cymbalta, call your healthcare provider orpoison control centerat 1-800-222-1222 right away, or get emergency treatment.

When switching from anotherantidepressantto Cymbalta your healthcare provider

Take Wellbutrin exactly as prescribed by yourdoctor.

• Take Wellbutrin at the same time each day.
• Take your doses of Wellbutrin at least 6 hours apart.
• You may take Wellbutrin with or without food.
• If you miss a dose, do not take an extratabletto make up for the dose you forgot. Wait and take your next tablet at the regular time. This is very important. Too much Wellbutrin can increase your chance of having a seizure.
• If you take too much Wellbutrin, or overdose, call your local emergency room orpoisoncontrolcenter right away.
• Do not take any other medicines while using Wellbutrin unless your doctor has told you it is okay.
• It may take several weeks for you to feel that Wellbutrin is working. Once you feel better, it is important to keep taking Wellbutrin exactly as directed by your doctor. Call your doctor if you do not feel Wellbutrin is working for you.
• Do not change your dose or stop taking Wellbutrin without talking with your doctor first.