What Is Cholestyramine and How Does It Work?
Cholestyramineis a prescription medication used to treatHyperlipidemia.
- Cholestyramine is available under the following different brand names:Prevalite,Questran,Questran Light, LoCholest.
What Are Dosages of Cholestyramine?
Adult dosage
Packet
- 4g
Powder for Oral Suspension
Adult dosage
- 4g/dose (231g)
- 4g/dose (378g)
- 4g/dose (210g)
Pediatric dosage
- 4g resin/5g powder
- 4g resin/5.5g powder
- 4g resin/5.7g powder
- 4g resin/6.4g powder
- 4g resin/9g powder
Hyperlipidemia
Adult dosage
- 4 g orally every 12-24 hours; increase gradually over 1-month intervals
- Maintenance: 8-16 g/day orally divided every 12 hours; not to exceed 24 g/day
Pediatric dosage
- 240 mg/kg/day orally divided every 8-12 hours; generally not to exceed 8 g/day
Dosage Considerations – Should be Given as Follows:
- See "Dosages."
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Common side effects of Cholestyramine include:
- mild constipation,
- diarrhea,
- stomach pain,
- nausea,
- loss of appetite,
- bloating or gas,
- irritation of the tongue, and
- itching or irritation around yourrectalarea
Serious side effects of Cholestyramine include:
- hives,
- difficulty breathing,
- swelling of the face, lips, tongue, or throat,
- ongoing or worsening constipation,
- severe stomach pain,
- blood in the urine,
- black, bloody, or tarry stools,
- easy bruising, and
- unusual bleeding
Rare side effects of Cholestyramine include:
- none
What Other Drugs Interact with Cholestyramine?
If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
- Cholestyramine has severe interactions with the following drug:
- 消胆胺有严重的交互没有加班her drugs.
- Cholestyramine has moderate interactions with at least 65 other drugs.
- Cholestyramine has minor interactions with the following drugs:
- acetaminophen
- acetaminophen IV
- acetaminophen rectal
- chenodiol
- ursodiol
- vitamin A
- vitamin K1 (phytonadione)
This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this drug, tell your doctor or pharmacist of all the drugs you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.
What Are Warnings and Precautions for Cholestyramine?
Contraindications
Effects of drug abuse
- None
Short-Term Effects
- See “What Are Side Effects Associated with Using Cholestyramine?”
Long-Term Effects
- See “What Are Side Effects Associated with Using Cholestyramine?”
Cautions
- Use with caution in renal impairment
- Volume depletion
- Concomitantspironolactonetherapy
- Not for use with baseline fasting triglyceride levels over 300 mg/dL or type III hyperlipoproteinemia; use with caution in patients with triglyceride levels 250-299 mg/dL; perform fastinglipidpanel in 4-6weeks after initiation; discontinue use iftriglyceridesare over 400 mg/dL; secondary causes of hyperlipidemia must be ruled out before therapy is initiated
- Not to be used as monotherapy in hypertriglyceridemia
- With prolonged use, increased risk of bleeding because of hypoprothrombinemia fromvitamin Kdeficiency
- May interfere with fat absorption and decrease absorption of fat-soluble vitamins (A, D, E, K)
- May exacerbate preexisting constipation (initiate therapy at lower dosage in patients with history of constipation)
- Special care must be taken to avoid constipation in patients with symptomatic coronaryheart disease
- Always mix with water or fluids; never ingest dry powder
- Some formulations containphenylalanine
- Because of large quantities of chloride ion released from resin (which may lead to hyperchloremicacidosisand increase urinary calcium excretion on prolonged use), it may be advisable to reduce chloride intake
- Take other drugs at least 1 hour before or 4-6 hours after taking cholestyramine to minimize possible interference with absorption
Pregnancy and Lactation
- Use with caution if benefits outweigh risks during pregnancy.
- Lactation: Drug does not enter breast milk; use with caution because of potential vitamin loss in the mother.
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https://reference.medscape.com/drug/prevalite-questran-cholestyramine-342448