Cefaclor

Cefacloris a prescription medication which is a cephalosporin-typeantibioticused to treat a wide variety of bacterial infections (middle ear, skin, urine and respiratory tract infections). It works by stopping the growth of bacteria.

Cefaclor only treats bacterial infections. It will not work for viral infections (common coldor the flu). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.

氯氨苄青霉素th下是可用的e following different brand names: Ceclor and Raniclor.

Adult, Pediatric and Geriatric:

Capsule

• 250 mg
• 500 mg

Dosing Considerations – Should be Given as Follows:

Infections

Adult and geriatric dosage:

• 250-500 mg orally every 8 hours

Pediatric:

• Infants less than 1 month old: safety and efficacy not established
• Infants older than 1 month: 20-40 mg/kg/day orally divided every 8 hours; not to exceed 1gram/day

Renal Impairment

• Creatinine clearance: 10-50 ml/ min: half to full dose
• Creatinine clearance: under 10 ml/min: half dose

Other Indications and uses:

• E. coli, H. influenza, Klepsiella spp., P. mirabilis, Straphylococci, group A beta-hemolytic streptococci

Common Side effects of Cefaclor include:

• diarrhea
• increased transaminases
• increased eosinophils in the blood
• yeast infectionin the mouth and throat
• vaginal infection
• rash (maculopapular, erythematous, or morbiliform)
• Stevens-Johnson syndrome
• inflammation of thecolon
• nausea
• vomiting
• anemia
• lowwhite blood cell count
• yellowing skin and eyes (jaundice)
• hypersensitivity
• itching
• hives
• positive Coombs' test
• acute skin condition
• arthritis
• joint pain
• fever
• enlargement of lymph nodes
• protein in urine
• toxic epidermal necrolysis
• severe allergic reaction
• skin swelling
• weakness, lack of energy
• swelling (including face and limbs)
• shortness of breath
• numbness and tingling
• fainting
• high blood pressure(hypertension)
• decreased blood pressure
• hepatitis
• liver diseasedue tobileblockage
• vaginal itching
• low bloodplatelet count
• swelling in the kidney
• hyperactivity
• agitation
• nervousness
• insomnia
• confusion
• rigid muscles
• dizziness
• hallucinations
• sleepiness
• elevations of liver functions (AST, ALT or alkaline phosphatase)
• increase of lymphocytes in the blood
• reduction of红细胞
• reduction in blood cells
• severely low white blood cell count
• 斯莱t elevations inBUNor serum creatinine
• abnormal urinalysisv

Rare side effects of cefaclor include:

• increasedcoagulationtime of the blood

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

• Cefaclor has no known severe interactions with other drugs.
• Serious interactions of cefaclor include:
  • BCG vaccinelive
  • cholear vaccine
  • typhoid vaccine live
• Moderate interactions of cefaclor include:
  • bazedoxifene/conjugatedestrogens
  • dienogest/estradiolvalerate
  • estradiol
  • ethinylestradiol
  • mestranol
  • 丙磺舒
  • sodium picosulfate/magnesium oxide/anhydrous citric acid
  • warfarin
• Mild interactions of cefaclor include:
  • bendroflumethiazide
  • chloramphenicol
  • choline magnesium trialicylate
  • furosemide
  • piroxicam
  • rose hips
  • salicylates (non-ASA)
  • sulfasalazine
  • willow bark

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

Warnings

• This medication contains cefaclor. Do not take Ceclor or Raniclor if you are allergic to cefaclor or any ingredients contained in this drug
• Keep out of reach of children
• In case of overdose, get medical help or contact a Poison Control Center immediately

Contraindications

• Documented hypersensitivity

Effects of Drug Abuse

• No information available

Short-Term Effects

• See "What Are Side Effects Associated with Using Cefaclor?"

Long-Term Effects

• Bacterial or fungal overgrowth of non-susceptible organisms may occur with prolonged or repeated therapy
• See "What Are Side Effects Associated with Using Cefaclor?"

Cautions

• Safety and efficacy of extended release tablets not established in children younger than 16 years of age
• Reduce dosage by 1/2 if creatinine clearance is 10-30 mL/min, and by 3/4 if under 10 mL/min (high doses may causecentral nervous systemtoxicity). Bacterial or fungal overgrowth of non-susceptible organisms may occur with prolonged or repeated therapy

Pregnancy and Lactation

• Use of cefaclor during pregnancy may be acceptable
• Either animal studies show no risk but human studies are not available or animal studies showed minor risks and human studies were done and showed no risk
• Cefaclor enters breast milk; use with caution if breastfeeding