布美他尼

布美他尼is used to reduce extra fluid in the body (edema) caused by conditions such ascongestive heart failure,liver disease, and kidney disease. Getting rid of extra water helps to reduce fluid in thelungsso that you can breathe easier. It also helps to decrease swelling of the arms, legs, and stomach/abdomen. Bumetanide is known as adiuretic(the same kind of drug as a "water pill"). It causes your body to get rid of extra water by increasing the amount of urine you make.

• 布美他尼is available under the following different brand names:Bumex, and Burinex.

Dosages of Bumetanide:

Adult and pediatric dosages:

Injectable solution

• 0.25 mg/ml

Tablet

• 0.5 mg
• 1 mg
• 2 mg

Dosage Considerations – Should be Given as Follows:

Edema in Adults

• Orally: 0.5-2 mg once; may be repeated in 4-5 hours for up to 2 doses; not to exceed 10 mg/day
• Intramuscular: 0.5-1 mg once; may be repeated in 2-3 hours for up to 2 doses; not to exceeded 10 mg/day
• Intravenously: 1 mg initially, then 0.5-2 mg/hour

Pediatric (off-label)

• Infants under 6 months: 0.01-0.05 mg/kg once daily or every other day; the optimum diuretic effect is reported at 0.04 mg/kg; lower dosages have been shown to have greater efficacy
• Infants 6 months and older: 0.015-.01 mg/kg once daily or every other day; not to exceed 10 mg/day

Hypertension(off-label)

• 1 mg intravenous loading dose, then 0.5-2 mg/day orally divided every 12 hours

Geriatric

Dosing Considerations

1 mg bumetanide is roughly equivalent to 40 mgfurosemide

• Edema due to congestiveheart failure, hepatic disease, or nephrotic syndrome
  • Use with fluid retentionrefractoryto thiazides or with impaired renal function
  • It may be tried if the patient is allergic to furosemide

Overdose Management

• Normal salinemay be used for volume replacement
• Dopamineor去甲肾上腺素may be used to treathypotension
• Treathyperkalemiawith intravenous glucose (D25W) with rapid-actinginsulinand concurrent intravenoussodium bicarbonate; use oral andrectalsolutions of sodium polystyrene insorbitolif needed
• If dysrhythmia due to decreasedpotassiumor magnesium is suspected, replace aggressively
• Discontinue treatment if no symptoms are apparent after 6 hours

Side effects of bumetanide include:

• high blooduric acidlevels
• low blood calcium levels
• low blood potassium levels
• highblood urea nitrogen(BUN)
• low blood sodium
• high blood sugar(hyperglycemia)
• increased serum creatinine
• variations in phosphorus
• variations in CO2 content
• variations inbicarbonate
• variations in calcium
• variations in protein in the红细胞
• clotting time for the blood
• red blood cell count
• lowplatelet count
• dizziness
• muscle cramps
• damage to the inner ear
• tremorof the hand
• dehydration
• low blood pressure(hypotension)
• dizziness upon standing
• itching
• rash
• kidney (renal) failure
• serious skin reactions (Stevens-Johnson syndrome,toxic epidermal necrolysis)
• spinning sensation (vertigo)
• vomiting
• headache
• nausea
• brain disease
• electrocardiogramchanges
• weakness
• abdominal pain
• arthritic pain
• musculoskeletal pain
• chest pain
• sweating
• hyperventilation
• dry mouth
• nippletenderness
• diarrhea
• prematureejaculation
• difficulty maintaining an erection

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

如果你的医生指导你使用这个书tion, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• 布美他尼has no known severe interactions with other drugs.
• Serious Interactions of bumetanide include:
  • amikacin
  • amisulpride
  • cisapride
  • gentamicin
  • kanamycin
  • neomycin (oral)
  • netilmicin
  • paromomycin
  • squill
  • streptomycin
  • tobramycin
• 布美他尼has moderate interactions with at least 148 different drugs.
• 布美他尼has mild interactions with at least 86 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns, or for more information about this medicine.

Warnings

• 布美他尼is a potent diuretic that, if given in excessive amounts, may lead to a profounddiuresiswith water andelectrolytedepletion
• Careful medical supervision is required; dosing must be adjusted to the patient's needs
• This medication contains bumetanide. Do not take Bumex or Burinex if you are allergic to bumetanide or any ingredients contained in this drug
• Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately

Contraindications

• Documented hypersensitivity to bumetanide orsulfonamides
• Severe uncorrected electrolyte depletion, anuria, hepatic coma

Effects of Drug Abuse

• No information available

Short-Term Effects

• See "What Are Side Effects Associated with Using Bumetanide?"

Long-Term Effects

• See "What Are Side Effects Associated with Using Bumetanide?"

Cautions

• Risk of electrolyte imbalance, alterations in glucosemetabolism, blood dyscrasias, development ofoliguriaor increased bloodureanitrogen (BUN) or creatinine, hepatic disease,hyperuricemia,hypokalemia,hypomagnesemia,hypovolemia, neonates at risk for kernicterus
• Risk ofototoxicitywith rapid intravenous (IV) administration
• Fluid status and renal function should be monitored to prevent oliguria, increased creatinine and BUN, andazotemia
• Asymptomatic hyperuricemia is reported
• Use with caution in patients withcirrhosis
• Coadministration with anantihypertensiveagent may increase the risk of hypotension

Pregnancy and Lactation

• Use bumetanide during pregnancy with caution if benefits outweigh risks
• Animal studies show risk and human studies are not available, or neither animal nor human studies were done
• It is unknown if bumetanide is excreted in breast milk; use with caution if breastfeeding