Aromatase:Anenzymeinvolvedinthe production ofestrogenthat acts by catalyzing the conversion oftestosterone(anandrogen) toestradiol(an estrogen).Aromataseis located in estrogen-producing cells in the adrenal glands, ovaries,placenta,testicles,adipose(fat)组织, andbrain.
The growth of somebreastcancers is promoted by estrogens. For example, the drugletrozole(brand name:Femara) is anantiestrogensometimes used to treat such estrogen-dependent tumors. The drug acts by inhibiting the enzyme aromatase which lowers the level of the estrogen, estradiol.
