How Do Antihistamine Piperazine Derivatives Work?

Antihistamine piperazine derivatives arehistamineH-1receptorantagonists used to treatanxiety,chronicurticaria(skinrash与foodallergy), pruritis (itching), andpreoperativesedation.

Hydroxyzineis an inverseagonistof histamine H-1 receptor which decreases the activity of the receptor and inhibits the release of histamine. This resultsininhibition ofsmooth musclecontractions and prevents bronchoconstriction,vasoconstriction, andspasmofgastrointestinalsmoothmuscle．羟嗪展览一个tiemetic properties and is an effective anxiolytic. Hydroxyzine crosses theblood-brain barrierand produces ananticholinergiceffect, as it blocks the action of theneurotransmitteracetylcholinein thecentral nervous system(brain) and produces sedation.

Antihistamine piperazine derivatives are used to treat:

• Anxiety
• Pruritis (itching)
• Chronic urticaria (skin rash associated with food allergy)
• Preoperative sedation

Off-label useincludes:

• Nauseaand vomiting

Some of the side effects associated with antihistamine piperazine derivatives may include:

• Headache
• Dry mouth
• Drowsiness
• Tremors
• Skin rash and itching
• Anaphylaxis(life-threatening allergic reactions)

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with yourdoctororpharmacistto make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking yourmedicationand never change your dose or frequency without consulting your doctor.

Genericand brand names of antihistamine piperazine derivatives include:

• Hydroxyzine
• Vistaril