Aldactone vs. Inspra (Eplerenone)

• Are Aldactone and Eplerenone (Inspra) the Same Thing?
• What Are Possible Side Effects of Aldactone?
• What Are Possible Side Effects of Eplerenone (Inspra)?
• What Is Aldactone?
• What Is Eplerenone (Inspra)?
• What Drugs Interact with Aldactone?
• What Drugs Interact with Eplerenone (Inspra)?
• How Should Aldactone Be Taken?
• How Should Eplerenone (Inspra) Be Taken?

Aldactone(spironolactone) and eplerenone are醛固酮receptorblockers used to reduce fluid retention (水肿) caused byheart,liverorkidneyproblems, andhigh blood pressure(hypertension).

螺内酯也用于治疗certain patients withhyperaldosteronism.

A brand name for eplerenone isInspra.

Commonside effectsof Aldactone include:

• skinrash,
• headache,
• dizziness,
• nausea,
• vomiting,
• gas, and
• stomachpain.

Tell yourdoctorif you have serious side effects of Aldactone including irregularheart rate,musclepain or weakness, urinating less than usual, shallowbreathing, tremors, confusion, or a severe skin reaction,hyperkalemia(high levels ofpotassiumintheblood), and numbness.

Common side effects of Eplerenone (Inspra) include:

• headache,
• dizziness,
• diarrhea,
• stomach pain,
• nausea,
• coughorflu-like symptoms (such asfever,chills, body aches, unusualtiredness),
• vaginal bleeding, or
• breastswelling or tenderness.

Tell your doctor if you have rare but serious side effects of Inspra including:

• abnormalvaginal bleeding,
• enlarged orsorebreasts in males, or
• symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat).

Aldactone (spironolactone) is an aldosterone receptorantagonistthat causes the kidneys to removewaterandsodiumfrom the body, with reduced losses of potassium. Aldactone is used to reduce edema caused by heart, liver or kidney problems, highblood pressure(hypertension), and certain patients with hyperaldosteronism.

Inspra (eplerenone) is an aldosterone receptor blocker, which is anantihypertensive, used to treatcongestive heart failureafter aheart attack, and is also used to treat high blood pressure (hypertension). Inspra is available ingenericform.

Aldactone may interact withlithiumor steroids.

Aldactone may also interact with other medicines that make you sleepy (such as cold orallergymedicine, sedatives,narcoticpain medicine, sleeping pills, muscle relaxers, and medicine for seizures,depression, oranxiety),digoxin,ACE inhibitors, or nonsteroidalanti-inflammatory drugs (NSAIDs).

Inspra may interact with lithium, other blood pressure medications, antibiotics, antifungals, ACE inhibitors, NSAIDs (non-steroidal anti-inflammatory drugs),HIV/AIDSmedicines, orantidepressants. Tell your doctor all medications you are taking.

Aldactone is available in 25, 50 and 100mgtablets. Because oftumorformation in experimental animals, use inpregnancyshould be avoided unless the benefits outweigh the potential risks to thefetus; women who arebreastfeedingare advised not to use Aldactone. In addition, the drug should not be used to decrease the normal edema of pregnancy. An active metabolite of Aldactone appears inbreast milk. Breastfeeding while using Aldactone is not recommended. If use of Aldactone is deemedessential, an alternative method ofinfantfeeding should be used.

Treatment with Inspra is initiated at 25 mg once daily and adjusted to the recommended dose of 50 mg once daily, preferably within 4 weeks as tolerated by thepatient.