Absolute neutrophil count:实际数量的白细胞(白细胞)re neutrophils. Theabsolute neutrophil countis commonly called the ANC.
The ANC is not measured directly. It is derived by multiplying the WBC count times the percent of neutrophils in the differential WBC count. The percent of neutrophils consists of the segmented (fully mature) neutrophils) + the bands (almost mature neutrophils). Thenormal rangefor the ANC = 1.5 to 8.0 (1,500 to 8,000/mm3).
Sample calculation of the ANC:
WBC count: 6,000 cells/mm3 of blood
Segs: 30% of the WBCs
Bands: 3% of the WBCs
Neutrophils (segs + bands): 33% of the WBCs
ANC: 33% X 6,000 = 2,000/mm3
ANC of 2,000/mm3, by convention = 2.0
Normal range: 1.5 to 8.0 (1,500 to 8,000/mm3)
Interpretation: Normal
Neutrophils are key components in the system of defense against infection. An absence or scarcity of neutrophils (a condition calledneutropenia) makes a person vulnerable to infection. Afterchemotherapy,radiation, or a blood or marrow transplant, the ANC is usually depressed and then slowly rises, reflecting the fact that thebone marrowis recovering and new blood cells are beginning to grow and mature.
In practical clinical terms, a normal ANC is 1.5 or higher; a "safe" ANC is 500-1500; a low ANC is less than 500. A safe ANC means that the patient's activities do not need to be restricted (on the basis of the ANC).
